Abstract: Objective To explore the associations of high sensitivity C-reactive protein (hsCRP) in the second trimester of pregnancy with gestational diabetes mellitus（GDM）and glucose related traits. Methods 725 women with GDM and 935 women who remained euglycemic throughout pregnancy were enrolled in this study. Pre-pregnancy weight、height and blood pressure were recorded and hsCRP、glucose and insulin levels were detected at 24 to 28 weeks of pregnancy. The associations of hsCRP levels with the blood glucose and insulin levels were analyzed，meanwhile, we also researched the associations of hsCRP with the occurrence of GDM. Results The hsCRP levels in the second trimester of pregnancy were significantly increased in GDM subjects compared with subjects with normal glucose tolerance（NGT）（p<0.01）. Elevated hsCRP was an independent risk factor for GDM（p<0.05）.Fasting blood glucose was associated with hsCRP（P<0.05）;1 h blood glucose after oral 50 grams of sugar was related to hsCRP（P<0.05）; 1，2 and 3h blood glucose after 100 grams OGTT were related to hsCRP（P<0.05）; glycosylated hemoglobin(HbA1c) was related to hsCRP（P<0.05）; fasting plasma insulin was related to hsCRP（P<0.05）;1,2 and 3h true insulin after 100 grams OGTT were related to hsCRP（P<0.05）;HOMA-IR was associated with hsCRP（P<0.05）.Conclusions The elevated hsCRP levels in the second trimester of pregnancy could significantly increase the risk of GDM，which is expected to become one of markers for the diagnosis of GDM.

Key words: gestational diabetes mellitus, hsCRP, HOMA-IR, glucose, true insulin