Abstract: Environmental factors and lifestyle have become a hot public concern in the inducement of pancreatic cancer, disease and individual factors can also provide some guidance for high-risk groups. The mechanism during the pancreatic cancer have complex signaling networks, including such as MAPK, Wnt, Notch, Hedgehog and PI3K / AKT signaling pathway.

Key words: inducement, signaling pathway, environmental cues, pancreatic cancer