Abstract: Radiation-induced cognitive impairment is hypothesized to occur because of dynamic interactions between multiple cell types, including astrocytes, endothelial cells, microglia, neurons, and oligodendrocytes. The precent studies indicate that radiation-induced changes include the decrease in hippocampus neurogenesis, alterations of neuronal functions, particularly synaptic plasticity, as well as the elevation of neuroinflammatory cytokines.

Key words: Radiation, Cognitive impairment, Neurogenesis, Neuronal function, Neuroinflammation