Abstract: Objective To study the effect of rh-GCSF on wound healing after treatment of chemotherapy and surgery in rabbits ,and the effect of VEGF and TNF-α. Methods New Zealand white rabbits (24cases),were randomly divided into 3 groups: normal group(8cases) was given surgery and medication, control group(8cases) and treatment group(8cases) were given infusion of epirubicin on the day before the operation，control group was treated as routine and treatment group was given rh-GCSF. Results The differences were observed including wound healing, VEGF and TNF-α in 7th day after surgery. The VEGF in treatment group was increased and the wound healing was better than the control group, but there was no difference of TNF-α in treatment and control group. Conclusion The rh-GCSF can increase the VEGF expression of incision sites, and it is helpful to wound healing after treatment with both chemotherapy and surgery.

Key words: rh-GCSF, Chemotherapy, Surgery, VEGF, TNF-a, Wound healing