Research progress of perforin 2

doi:10.16352/j.issn.1001-6325.2025.04.0542

Abstract

Abstract: Perforin 2 (MPEG 1) is a member of the MACPF(membrane attack complex/PRF membrane attack complex/perforin) superfamily, which is mainly secreted by cytotoxic T lymphocytes, natural killer cells and macrophages Through the formation of active pores on the target cell membrane, perforin 2 participates in altering the permeability-pressure of the target cell, or collaborates with granzymes to induce the apoptosis of target cells. Recently, with the development of molecular biology, MPEG 1 has been increasingly studied, and the unique gene sequence and cell types of perforin 2 have specific functions and adaptive evolution in different immune cells, which may determine its performance and therapeutic potential in different disease states.

Key words: perforin 2, MPEG 1, membrane attack complex perforin, poroprotein

CLC Number:

R392

DENG Zhiyuan, BAI Lu, YU Rong. Research progress of perforin 2[J]. Basic & Clinical Medicine, 2025, 45(4): 542-545.

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