Advances in the role of fibroblasts in gastroesophageal reflux disease

doi:10.16352/j.issn.1001-6325.2024.11.1594

Abstract

Abstract: Esophageal damage in gastroesophageal reflux disease (GERD) is a chronic inflammation, and fibroblasts, as esophageal stromal cells, play an important role in the oesophageal mucosal barrier and oesophageal inflammation. Fibroblasts are closely associated with the degree of disease progression in GERD, secreting large amounts of collagen to promote oesophageal mucosal barrier repair during oesophageal damage, regulating immune homeostasis through paracrine signaling, and interacting with immune cells. In addition to secreting inflammatory products, but inappropriate fibroblast activation can induce a pro-inflammatory response. Activation of fibroblasts induces pro-inflammatory and immunosuppressive properties promoting the presence of disease, suggesting that they may play a key role in disease progression.

Key words: gastroesophageal reflux disease, fibroblast, esophageal mucosa, esophageal inflammation

CLC Number:

R573

WANG Wei, SUN Yongshun. Advances in the role of fibroblasts in gastroesophageal reflux disease[J]. Basic & Clinical Medicine, 2024, 44(11): 1594-1597.

References

[1] Naylor AJ, Filer A, Buckley CD, et al. The role of stromal cells in the persistence of chronic inflammation[J]. Clin Exp Immunol,2013,171:30-35.
[2] Crowley T, Buckley CD, Clark AR, et al.Stroma: the forgotten cells of innate immune memory[J].Clin Exp Immunol, 2018,193:24-36.
[3] Muir AB, Wang JX, Nakagawa H, et al.Epithelial-stromal crosstalk and fibrosis in eosinophilic esophagitis[J].J Gastroenterol,2019,54:10-18.
[4] Souza RF, Bayeh L, Spechler SJ, et al. A new paradigm for GERD pathogenesis. Not acid injury, but cytokine-mediated inflammation driven by HIF-2α: a potential role for targeting HIF-2α to prevent and treat reflux esophagitis[J]. Curr Opin Pharmacol, 2017,37:93-99.
[5] Patankar M, Li M, Khalatbari A, et al. Inflammatory and proliferative pathway activation in human esophageal myofibroblasts treated with acidic bile salts[J].Int J Mol Sci, 2022,23:10371.doi:10.3390/ijms231810371.
[6] Nejat Pish-Kenari F, Qujeq D, Maghsoudi H, et al. Some of the effective factors in the patho genesis of gastro-oesophageal reflux disease[J]. J Cell Mol Med,2018,22:6401-6404.
[7] Davidson S, Coles M, Thomas T, et al. Fibroblasts as immune regulators in infection, inflammation and cancer[J].Nat Rev Immunol,2021,21:704-717.
[8] Muir AB, Dods K, Henry SJ, et al. Eosinophilic esophagitis-associated chemical and mechanical microenviron-ment shapes esophageal fibroblast behavior[J]. J Pediatr Gastroenterol Nutr, 2016,63:200-209.
[9] 李文殊,许宇饺,卓雅婷等. 成纤维细胞在皮肤创伤修复中的作用研究进展 [J]. 药学研究, 2021, 40: 191-195.
[10] Tarbit E, Singh I, Peart JN, et al. Biomarkers for the identification of cardiac fibroblast and myofibroblast cells[J].Heart Fail Rev,2019,24:1-15.
[11] Hartupee J, Mann DL, et al.Role of inflammatory cells in fibroblast activation[J].J Mol Cell Cardiol,2016,93:143-148.
[12] 陶朝宇,赵月萍. 肌成纤维细胞在糖尿病牙周炎牙周伤口愈合中作用的研究进展[J]. 中国现代医生, 2023, 61: 120-124.
[13] Doolin MT, Smith IM, Stroka KM, et al.Fibroblast to myofibroblast transition is enhanced by increased cell density[J].Mol Biol Cell,2021,32:ar41.doi:10.1091/mbc.E20-08-0536.
[14] 朱静,夏志军. 人阴道成纤维细胞功能紊乱与盆腔器官脱垂[J]. 国际妇产科学杂志, 2023, 50: 613-617.
[15] Krzysiek-Maczka G, Brzozowski T, Ptak-Belowska A, et al.Helicobacter pylori-activated fibroblasts as a silent partner in gastric cancer development[J]. Cancer Metastasis Rev,2023,42:1219-1256.
[16] Van Linthout S, Miteva K, Tschöpe C, et al.Crosstalk between fibroblasts and inflammatory cells[J].Cardiovasc Res, 2014,102:258-269.
[17] Chalkidi N, Paraskeva C, Koliaraki V, et al.Fibroblasts in intestinal homeostasis, damage, and repair[J]. Front Immunol,2022,13:924866.doi:10.3389/fimmu.2022.924866.
[18] Kirk T, Ahmed A, Rognoni E, et al. Fibroblast memory in development, homeostasis and disease[J]. Cells, 2021,10:2840. doi: 10.3390/cells10112840. PMID: 34831065; PMCID: PMC8616330.
[19] Turner JD, Naylor AJ, Buckley C, et al. Fibroblasts and osteoblasts in inflammation and bone damage[J]. Adv Exp Med Biol,2018,1060:37-54.
[20] 周昊,张颖倩,胡颖芸等. 巨噬细胞在心肌梗死后成纤维细胞激活中的作用 [J]. 中南医学科学杂志, 2023, 51: 824-828.
[21] Cavagnero KJ, Gallo RL, et al.Essential immune functions of fibroblasts in innate host defense[J]. Front Immunol,2022,13:1058862.doi:10.3389/fimmu.2022.1058862.
[22] Paish HL, Kalson NS, Smith GR, et al. Fibroblasts promote inflammation and pain via IL-1α induction of the monocyte chemoattractant chemokine (C-C Motif) ligand 2[J].Am J Pathol, 2018,188:696-714.
[23] Wei K, Nguyen HN, Brenner MB, et al. Fibroblast pathology in inflammatory diseases[J]. J Clin Invest,2021,131:e149538.doi:10.1172/JCT149538.