Research progress of metabolomics in the diagnosis and treatment of severe injuries

doi:10.16352/j.issn.1001-6325.2024.04.0562

Abstract

Abstract: Metabolomics is a novel emerging technology recently applied in management of severe diseases and trauma, and has been widely used in gene analysis of disease metabolic disorders, clinical biomarker screening and disease diagnosis. This review comprehensively summarizes the latest research progress of the metabolomics in severe trauma and burns recently like traumatic brain injury(TBI), traumatic hemorrhagic shock, severe burns and so on. The paper elaborates the metabolomic technology which can quickly reflect the real-time metabolic changes of severely injured patients at different stages after injury, and uncovers new clinical biomarkers and potential drug targets of the patients with severe injuries thus improves the diagnosis and treatment strategies. Finally, we look forward to the current metabolomics research projects and tackling challenges on the burn-blast combined injuries, and the simultaneous development of multi-omics technology as well as artificial intelligence algorithms, which promotes the development of precision medicine.

Key words: metabolomics, trauma, burn, burn-blast combined injury

CLC Number:

:R605.971

WEI Bin, DUAN Hongjie, CHAI Jiake. Research progress of metabolomics in the diagnosis and treatment of severe injuries[J]. Basic & Clinical Medicine, 2024, 44(4): 562-567.

References 24

[1]	Wishart DS, Cheng LL, Copie V, et al. NMR and metabolomics-a roadmap for the future[J]. Metabolites, 2022, 12: 678.doi: 10.3390/metabo12080678.
[2]	Sundekilde UK, Yde CC, Honore AH, et al. An integrated multi-omics analysis defines key pathway alterations in a diet-induced obesity mouse model[J]. Metabolites, 2020, 10: 80. doi: 10.3390/metabo10030080.
[3]	Bykowski EA, Petersson JN, Dukelow S, et al. Urinary metabolomic signatures as indicators of injury severity following traumatic brain injury: a pilot study[J]. IBRO Neurosci Rep, 2021, 11: 200-206.
[4]	Panyard DJ, Kim KM, Darst BF, et al. Cerebrospinal fluid metabolomics identifies 19 brain-related phenotype associations[J]. Commun Biol, 2021, 4: 63. doi: 10.1038/s42003-020-01583-z.
[5]	Thomas I, Dickens AM, Posti JP, et al. Serum metabolome associated with severity of acute traumatic brain injury[J]. Nat Commun, 2022, 13: 2545. doi:10.1038/s41467-022-30227-5.
[6]	Creech M, Carvalho L, McCoy H, et al. Mass spectrometry-based approaches for clinical biomarker discovery in traumatic brain injury[J]. Curr Treat Options Neurol, 2022, 24: 605-618.
[7]	Khellaf A, Garcia NM, Tajsic T, et al. Focally administered succinate improves cerebral metabolism in traumatic brain injury patients with mitochondrial dysfunction[J]. J Cereb Blood Flow Metab, 2022, 42: 39-55.
[8]	Laserna AKC, Lai Y, Fang G, et al. Metabolic profiling of a porcine combat trauma-Injury model using NMR and multi-mode LC-MS metabolomics-a prelimi-nary study[J]. Metabolites, 2020, 10:373. doi: 10.3390/metabo10090373.
[9]	Reisz JA, Wither MJ, Moore EE, et al. All animals are equal but some animals are more equal than others: Plasma lactate and succinate in hemorrhagic shock-a comparison in rodents, swine, nonhuman primates, and injured patients[J]. J Trauma Acute Care Surg, 2018, 84: 537-541.
[10]	LaCroix IS, Cohen M, Moore EE, et al. Omics markers of red blood cell transfusion in trauma[J]. Int J Mol Sci, 2022, 23:13815. doi: 10.3390/ijms232213815.
[11]	Huh Y, Ko Y, Hwang K, et al. Admission lactate and base deficit in predicting outcomes of pediatric trauma[J]. Shock, 2021, 55: 495-500.
[12]	Li M, Li G, Yu B, et al. Activation of hypoxia-inducible factor-1alpha via succinate dehydrogenase pathway during acute lung injury induced by trauma/hemorrhagic shock[J]. Shock, 2020, 53: 208-216.
[13]	Taghavi S, Abdullah S, Toraih E, et al. Dimethyl malonate slows succinate accumulation and preserves cardiac function in a swine model of hemorrhagic shock[J]. J Trauma Acute Care Surg, 2022, 93: 13-20.
[14]	Thooft A, Conotte R, Colet JM, et al. Serum metabolomic profiles in critically Ill patients with shock on admission to the Intensive care unit[J]. Metabolites, 2023, 13: 523. doi: 10.3390/metabo13040523.
[15]	Nakazawa H, Wong LP, Shelton L, et al. Farnesysltransferase inhibitor prevents burn injury-induced metabolome changes in muscle[J]. Metabolites, 2022, 12: 800. doi: 10.3390/metabo12090800.
[16]	彭曦. 重症烧伤患者的代谢分期及营养治疗策略[J]. 中华烧伤杂志, 2021, 37: 805-810.
[17]	Hendrickson C, Linden K, Kreyer S, et al.(1)H-NMR metabolomics identifies significant changes in metabolism over time in a porcine model of severe burn and smoke inhalation[J]. Metabolites, 2019, 9: 142. doi: 10.3390/metabo9070142.
[18]	Zhao Y, Liu J, Ding Z, et al. ATP-induced hypothermia improves burn injury and relieves burn pain in mice[J]. J Therm Biol, 2023, 114: 103563. doi: 10.1016/j.jtherbio.2023.103563.
[19]	Chen Z, Turxun N, Ning F. Meta-analysis of the diagno-stic value of procalcitonin in adult burn sepsis[J]. Adv Clin Exp Med, 2021, 30: 455-463.
[20]	Elmassry MM, Mudaliar NS, Colmer-Hamood JA, et al. New markers for sepsis caused by pseudomonas aeruginosa during burn infection[J]. Metabolomics, 2020, 16: 40. doi: 10.1007/s11306-020-01658-2.
[21]	董新文, 姚三巧, 吴卫东, 等. 瓦斯爆炸致大鼠复合伤的血清代谢组学变化研究[J]. 中华劳动卫生职业病杂志, 2021, 11: 808-814.
[22]	Dong X, Yao S, Wu W, et al. Gas explosion-induced acute blast lung injury assessment and biomarker identification by a LC-MS-based serum metabolomics analysis[J]. Hum Exp Toxicol, 2021, 40: 608-621.
[23]	Qiao J, Guo S, Huang X, et al. Expression of angio-poietin-2 in lung tissue of juvenile SD rats with lipopolysaccharide-induced acute lung injury and the role of ulinasta-tin[J]. Arch Immunol Ther Exp(Warsz), 2023, 71: 23. doi: 10.1007/s00005-023-00688-7.
[24]	谢锋, 柴家科, 胡泉, 等. 烧冲复合伤大鼠心肌损伤及钙蛋白酶的变化规律[J]. 中华医学杂志, 2017, 97: 3652-3657.[25.]Tao W, Concepcion AN, Vianen M, et al. Multiomics and machine learning accurately predict clinical response to adalimumab and etanercept therapy in patients with rheumatoid arthritis[J]. Arthritis Rheumatol, 2021, 73: 212-222.