Research progress on the role of HMGB1 signal pathway in bronchial asthma

doi:10.16352/j.issn.1001-6325.2023.04.0690

Abstract

Abstract: High mobility group box 1 protein (HMGB1), as a ubiquitous nuclear protein, expresses in almost all cells. After activation and release, HMGB1 binds to its receptor and mediates pulmonary inflammatory response. HMGB1 signaling pathway is closely related to the occurrence and development of bronchial asthma. Related targeted drug therapy has been carried out in animal test and in clinical trials.

Key words: HMGB1, bronchial asthma, airway inflammation, airway remodeling

CLC Number:

R563.9

SUN Ying, YANG Zhian, HE Yao, YU Qin. Research progress on the role of HMGB1 signal pathway in bronchial asthma[J]. Basic & Clinical Medicine, 2023, 43(4): 690-694.

References

[1]Vanpatten S, Alabed Y.High mobility group box-1 (HMGb1): current wisdom and advancement as a potential drug target[J]. 2018, 61: 5093-5107.
[2]Zhao J, Sun T, Wu S, et al. High mobility group box 1: an Immune-regulatory protein[J]. 2019, 19: 100-109.
[3]Deng M, Scott M J, Fan J, et al.Location is the key to function: HMGB1 in sepsis and trauma-induced inflammation[J]. J Leukocyte Biol, 2019, 106: 161-169.
[4]Scaffidi P, MisteliI T, Bianchi ME. Erratum: release of chromatin protein HMGB1 by necrotic cells triggers inflammation[J]. Nature,2002, 418: 191-195.
[5]Qu D, Ling Z, Tan X, et al. High mobility group protein B1 (HMGB1) interacts with receptor for advanced glycation end products (RAGE) to promote airway smooth muscle cell proliferation through ERK and NF-κB pathways[J]. Int J Clin Exp Pathol, 2019, 12: 3268-3278.
[6]Zhu X, Cong J, Yang B, et al. Association analysis of high-mobility group box-1 protein 1 (HMGB1)/toll-like receptor (TLR) 4 with nasal interleukins in allergic rhinitis patients[J]. Cytokine, 2020, 126:154880.
[7]Brandt EB, Lewkowich IP. RAGE-induced asthma: a role for the receptor for advanced glycation end-products in promoting allergic airway disease[J]. J Allergy Clin Immunol, 2019, 144: 651-653.
[8]Soliman NA, Abdel Ghafar MT, El Kolaley RM, et al. Cross talk between Hsp72, HMGB1 and RAGE/ERK1/2 signaling in the pathogenesis of bronchial asthma in obese patients[J]. Mol Biol Rep, 2020, 47: 4109-4116.
[9]Loh Z, Simpson J, Ullah A, et al. HMGB1 amplifies ILC2-induced type-2 inflammation and airway smooth muscle remodelling[J]. PLoS Pathogens, 2020, 16: e1008651.doi:10.1371/journal.ppat.1008651.
[10]Zhang F, Su X, Huang G, et al. sRAGE alleviates neutrophilic asthma by blocking HMGB1/RAGE signalling in airway dendritic cells[J]. Sci Rep, 2017, 7: 14268.doi:10.1038/s41598-017-14667-4.
[11]Arikkatt J, Ullah MA, Short KR, et al. RAGE defici-ency predisposes mice to virus-induced paucigranulocytic asthma[J]. eLife, 2017,6:e21199.doi:10.7554/eLife.21199.
[12]Zhang X, Xie J, Sun H, et al. sRAGE inhibits the mucus hypersecretion in a mouse model with neutrophilic asthma[J]. Immunol Invest, 2022,51:1243-1256.
[13]Tang H, Li T, Han X, et al. TLR4 antagonist ameliorates combined allergic rhinitis and asthma syndrome (CARAS) by reducing inflammatory monocytes infiltration in mice model[J]. Int Immunopharmacol, 2019,73:254-260.
[14]Tang H, Han X, Li T, et al. Protective effect of miR-138-5p inhibition modified human mesenchymal stem cell on ovalbumin-induced allergic rhinitis and asthma syndrome[J]. J Cell Mol Med, 2021, 25: 5038-5049.
[15]Liu T, Barrett NA, Kanaoka Y, et al. Cysteinyl leuko-triene receptor 2 drives lung immunopathology through a platelet and high mobility box 1-dependent mechanism[J]. Mucosal Immunol, 2019, 12: 679-690.
[16]Liu M, Shan M, Zhang Y, et al. Progranulin protects against airway remodeling through the modulation of autophagy via HMGB1 suppression in house dust mite-induced chronic asthma[J]. J Inflamm Res, 2021, 14:3891-3904.
[17]Yang N, Shang YX. Epigallocatechin gallate ameliorates airway inflammation by regulating Treg/Th17 imbalance in an asthmatic mouse model [J]. Int Immunopharmacol, 2019, 72:422-428.
[18]Li Y, Chen L, Guo F, et al. Effects of epigallocatechin-3-gallate on the HMGB1/RAGE pathway in PM2.5-exposed asthmatic rats[J]. Biochem Biophys Res Commun, 2019, 513: 898-903.
[19]Gu X, Shu D, Ying S, et al. Roxithromycin attenuates inflammation via modulation of RAGE-influenced calpro-tectin expression in a neutrophilic asthma model[J]. Ann Transl Med, 2021, 9: 494.doi:10.21037/atm-21-859.
[20]Allam V, Faiz A, Lam M, et al. RAGE and TLR4 differentially regulate airway hyperresponsiveness: Implications for COPD[J]. Allergy, 2021, 76: 1123-1135.
[21]Zhang H, Yang N, Wang T, et al. Vitamin D reduces inflammatory response in asthmatic mice through HMGB1/TLR4/NF-κB signaling pathway[J]. Mol Med Rep, 2018, 17: 2915-2920.
[22]Lu M, Litonjua AA, Oconnor GT, et al. Effect of early and late prenatal vitamin D and maternal asthma status on offspring asthma or recurrent wheeze[J]. J Allergy Clin Immunol, 2021, 147: 1234-1241.
[23]Forno E, Bacharier LB, Phipatanakul W, et al. Effect of vitamin D₃ supplementation on severe asthma exacerba-tions in children with asthma and low vitamin D levels: the VDKA randomized clinical trial[J]. JAMA, 2020, 324: 752-760.
[24]Shang J, Liu W, Yin C, et al. Cucurbitacin E ameliorates lipopolysaccharide-evoked injury, inflammation and MUC5AC expression in bronchial epithelial cells by restraining the HMGB1-TLR4-NF-κB signaling[J]. Mol Immunol, 2019, 114:571-577.
[25]Wang X, Gap Y, Yang Q, et al. Pingchuanning decoction attenuates airway inflammation by suppressing autophagy via phosphatidylinositol 3-kinase/protein kinase B/mammalian target of rapamycin signaling pathway in rat models of asthma[J]. J Cell Biochem, 2019, 120: 3833-3844.