Research progress of application of pharmaceutical preparation chitosan

doi:10.16352/j.issn.1001-6325.2022.11.1791

Abstract

Abstract: As the only alkaline polysaccharide in nature, chitosan(CTS) is haracterized by its unique physiological activity, good film-forming capacity, well adsorption and antibacterial properties. Various pharmaceutical preparations and clinical applications of CTS and its derivatives have proved the practicability of CTS products in the field of pharmaceutical preparations. CTS and its derivatives have a good development prospect in the field of medicine and clinical application.

Key words: chitosan, medicinal preparations, drug carrier, clinical application

CLC Number:

Q539

ZOU Xing-long, CHEN Zhu-xian, SUN Juan-juan, CAI Jiang-ying, SU Lu, MA Wei, FU Si-wu. Research progress of application of pharmaceutical preparation chitosan[J]. Basic & Clinical Medicine, 2022, 42(11): 1791-1794.

References 25

[1]	Santos VP,Marques N,Maia P,et al. Seafood waste as attractive source of chitin and chitosan production and their applications[J]. Int J Mol Sci, 2020,21:4290-4291.
[2]	Popescu R, Ghica MV, Dinu-Pîrvu CE, et al. New opportunity to formulate intranasal vaccines and drug delivery systems based on chitosan[J]. Int J Mol Sci, 2020,21:5016-5021.
[3]	Aquino RP, Auriemma G, Conte GM, et al. Development of chitosan/mannitol microparticles as delivery system for the oral administration of a spirulina bioactive peptide extract[J]. Molecules, 2020,25:2089-2098.
[4]	Gka A, Dbka B, Eko C. et al. Chitosan/poly(2-ethyl-2-oxazoline) films for ocular drug delivery: formulation, miscibility, in vitro and in vivo studies[J]. Eur Polym J, 2019,116:311-320.
[5]	Kravanja, Primoi, Knez, et al. Chitosan-based (nano)materials for novel biomedical applications[J]. Molecules, 2019,24:1960-1961.
[6]	Ibrahim HM,Mostafa M, Kandile NG. Potential use of N-carboxyethyl chitosan in biomedical applications: Preparation, characterization, biological properties[J].Int J Biol Macromol,2020,149:664-671.
[7]	Wang S, Sun Y, Zhang J, et al. Astragalus polysaccharides/chitosan microspheres for nasal delivery: preparation, optimization, characterization, and pharmacodynamics[J]. Front Pharmacol, 2020,11:230-237.
[8]	Chen J,Pan H,Duan H, et al. Self-assembled liposome from core-sheath chitosan-based fibres for buccal delivery of carvedilol: formulation, characterization and in vitro and ex vivo buccal absorption[J]. J Pharm Pharmacol,2020,72:343-355.
[9]	Li J, Cheng T, Tian Q, et al. A more efficient ocular delivery system of triamcinolone acetonide as eye drop to the posterior segment of the eye[J]. Drug deliv,2019,26:188-198.
[10]	陈莉娅,李平,王建民.复方壳聚糖口腔溃疡涂膜剂的制备及临床应用[J].中国医院药学杂志,2001,1:50-51.
[11]	夏联恒,张珈源,王佳鑫,等.李令根应用中药壳聚糖复合药膜治疗下肢慢性溃疡经验[J].北京中医,2019,38:1096-1098.
[12]	Muthiah Pillai NS, Eswar K, Amirthalingam S, et al. Injectable nano whitlockite incorporated chitosan hydrogel for effective hemostasis[J].ACTS Applied Bio Materials,2019,2:865-873,
[13]	Wang XL, Xu PC, Yao ZX, et al. Preparation of antimicrobial hyaluronic acid/quaternized chitosan hydrogels for the promotion of seawater-immersion wound healing[J]. Front. Bioeng. Biotechnol,2019,7:360-379.
[14]	Li J, Zhuang S. Antibacterial activity of chitosan and its derivatives and their interaction mechanism with bacteria: current state and perspectives[J]. Eur Polym J,2020,138:109984.doi:10.1016/j.eurpolymj.2020.109984.
[15]	Feng P, Luo Y, Ke C, et al. Chitosan-based functional materials for skin wound repair: mechanisms and applications[J]. Front BioengBiotechnol,2021,9:650598.doi:10.3389/fbioe.2021.650598
[16]	Matica MA, Aachmann FL, Tndervik A, et al. Chitosan as a wound dressing starting material: antimicrobial properties and mode of action[J].Int J Mol Sci,2019,20:5892-5896.
[17]	Randy C, Tzi N, Jack W, et al.Chitosan:an update on potential biomedical and pharmaceutical applications[J].Mar Drugs,2015,13:5156-5186.
[18]	Gibot L, Chabaud S, Bouhout S,et al.Anticancer properties of chitosan on human melanoma are cell line dependent[J].Int J Biol Macromol,2015,72:370-379.
[19]	Wu P,Yu SS,Liu C,et al. Seleno-Chitosan induces apoptosis of lung cancer cell line SPC-A-1 via fas/fasL pathway[J].Bioorganic Chemistry,2020,97:103701.doi:10.1016/j.bioorg.2020.103701.Bioconjug Chem.
[20]	Jones M, Kujundzic M, John S, et al.Crab vs. mush-room: a review of crustacean and fungal chitin in wound treatment. marine drugs[J].Mar Drugs, 2020,18:69-72.
[21]	Chen X,Zhang M,Wang X,et al.Peptide-modified chitosan hydrogels promote skin wound healing by enhancing wound angio-genesis and inhibiting inflammation[J].Am J Transl Res,2017,9:2352-2362.
[22]	Kaparekar PS,Pathmanapan S,Anandasadagopan SK. Polymeric scaffold of gallic acid loaded chitosan nanoparticles infused with collagen-fibrin for wound dressing application[J].Int J Biol Macromo,2020,165:930-947.
[23]	郎咸征.评价壳聚糖抗菌凝胶治疗混合性阴道炎的临床疗效[J].中国医药指南,2018,16:111-112.
[24]	Lo WH, Deng FS, Chang CJ,et al.Synergistic antifungal activity of chitosan with fluconazole against candida albicans,candida tropicalis,and fluconazole-resistant strains[J]. Molecules,2020,25:5114-5126.
[25]	刘燕,周静,李玲.阴道镜下宫颈活检术后止血方法的运用[J].全科护理,2019,17:2095-2098.