Research progress of the role of Kisspeptin in puberty onset

doi:10.16352/j.issn.1001-6325.2022.10.1601

Abstract

Abstract: Kisspeptin activates the hypothalamic-pituitary-gonadal axis (HPGA) and regulates the pulsatile secretion of gonadotropin-releasing hormone (GnRH) through KNDy neurons, thereby regulating the initiation of the pubertal phase. This review focuses on the mechanism of GnRH regulation by Kisspeptin and the role of Kisspeptin in the hypothalamic, pituitary and ovarian, aiming to provide reference for clinical management of abnormal pubertal development.

Key words: puberty onset, Kisspeptin, GnRH, hypothalamic pituitary gonadal axis, KNDy neurons

CLC Number:

R335

ZHAO Zi-jun, MA Wei. Research progress of the role of Kisspeptin in puberty onset[J]. Basic & Clinical Medicine, 2022, 42(10): 1601-1605.

References 24

[1]	Zhu N, Zhao M, Song Y, et al. The KiSS-1/GPR54 system: Essential roles in physiological homeostasis and cancer biology[J].Genes Dis, 2020,9:28-40.
[2]	Sobrino V, Avendaño MS, Perdices-López C, et al. Kisspeptins and the neuroendocrine control of reproduction: Recent progress and new frontiers in kisspeptin research[J].Front Neuroendocrinol, 2022,65:100977. doi: 10.1016/j.yfrne.2021.100977。
[3]	Spaziani M, Tarantino C, Tahani N, et al. Hypothalamo-Pituitary axis and puberty[J]. Mol Cell Endocrinol, 2021,520:111094.
[4]	苏彦捷,姜玮丽,魏祺,等.是什么引发了青春期?[J].科学通报,2017,62:749-758.
[5]	Uenoyama Y, Nagae M, Tsuchida H, et al. Role of KNDy neurons expressing kisspept-in, neurokinin B, and dynorphin A as a GnRH pulse generator controlling mammalian reproduction[J]. Front Endocrinol (Lausanne), 2021,12:724632.doi: 10.3389/fendo.2021.724632.
[6]	Abbara A, Dhillo WS. Targeting elevated GnRH pulsati-lity to treat polycystic ovary syndrome[J]. J Clin Endocrinol Metab, 2021,106:4275. doi: 10.1210/clinem/dgab422.
[7]	Valsassina R, Briosa F, Soares J,et al. Hypogonadotropic hypogonadism due to compound heterozygous mutations TACR3 in siblings[J].Clin Case Rep, 2020,8:3126-3129. doi: 10.1002/ccr3.3370.
[8]	李海玲,司文宇,宋爽,等.外源性神经激肽B对雌性大鼠生殖轴GnRH和Kisspeptin表达的影响[J].中国农业大学学报, 2021,26:69-77.
[9]	Liu Y, Li X, Ivanova D, et al. Dynorphin and GABAA receptor signaling contribute to progesterone's inhibition of the LH surge in female mice[J].Endocrinology, 2020,161:bqaa036. doi: 10.1210/endocr/bqaa036.
[10]	Wakabayashi Y, Okamura H, Yamamura T. Local administration of neurokinin B in the arcuate nucleus accelerates the neural activity of the GnRH pulse generator in goats[J]. J Reprod Dev, 2021,67:352-358.
[11]	Aerts EG, Harlow K, Griesgraber MJ, et al. Kisspeptin, neurokinin B, and dynorphin expression during pubertal development in female sheep[J].Biology (Basel), 2021,10:988. doi: 10.3390/biology10100988.
[12]	Zmijewska A, Czelejewska W, Dziekonski M, et al. Effect of kisspeptin and RF amide-related peptide-3 on the synthesis and secretion of LH by pituitary cells of pigs during the estrous cycle[J].Anim Reprod Sci, 2020,214:106275. doi: 10.1016/j.anireprosci.2020.106275.
[13]	Kim NN, Choi YU, Park HS, et al. Kisspeptin regulates the somatic growth-related factors of the cinnamon clownfish Amphiprion melanopus[J]. Comp Biochem Physiol A Mol Integr Physiol, 2015,179:17-24.
[14]	Stallings CE, Kapali J, Ellsworth BS. Mouse models of gonadotrope development[J].Prog Mol Biol Transl Sci, 2016,143:1-48.
[15]	Hashizume T, Saito H, Sawada T, et al. Characteristics of stimulation of gonadotropin secretion by Kisspeptin-10 in female goats[J].Anim Reprod Sci, 2010,118:37-41.
[16]	Hu KL, Zhao H, Chang HM, et al. Kisspeptin/Kisspeptin receptor system in the ovary[J].Front Cell Endocrinol, 2017,8:365. doi: 10.3389/fendo.
[17]	Ruohonen ST, Gaytan F, Gaudi AU, et al. Kisspeptin signaling in oocytes is compulsory for ovulation in adult mice[J]. FASEB J, 2019, 33(S1):580.5-580.5.
[18]	Zhai J, Ding L, Zhao S, et al. Kisspeptin: a new marker for human pre-ovulation[J]. Gynecol Endocrinol, 2017,33:560-563.
[19]	王丁丁. GnRH泵治疗低促性腺激素性性腺功能减退青少年患者的有效性和安全性[D].山东大学,2017.
[20]	de Roux N, Genin E, Carel JC, et al. Hypogonadotropic hypogonadism due to loss of function of the KiSS1-derived peptide receptor GPR54[J]. Proc Natl Acad Sci U S A,2003,100:10972-10976.
[21]	Nalbantoğlu Ö, Arslan G, Köprülü Ö, et al. Three siblings with idiopathic hypogonadotropic hypogonadism in a nonconsanguineous family: a novel KISS1R/GPR54 loss-of-function mutation[J]. J Clin Res Pediatr Endocrinol, 2019,11:444-448.
[22]	Canton APM, Seraphim CE, Brito VN, et al. Pioneering studies on monogenic central precocious puberty[J]. Arch Endocrinol Metab, 2019,63:438-444.
[23]	Li M, Chen Y, Liao B, et al. The role of Kisspeptin and MKRN3 in the diagnosis of central precocious puberty in girls[J]. Endocr Connect, 2021,10:1147-1154.
[24]	Zou P, Wang X, Chen Q, et al. Kisspeptin protein in seminal plasma is positively associated with semen quality: results from the MARHCS study in Chongqing, China[J]. Biomed Res Int, 2019,2019:5129263. doi: 10.1155/2019/5129263.