Research progress on mechanism of Schwann cells promoting peripheral nerve regeneration

doi:10.16352/j.issn.1001-6325.2022.01.020

Abstract

Abstract: Schwann cells (SCs) have a strong plasticity. After peripheral nerve injury, Schwann cells dedifferentiate into repair phenotype and dominate the repair process. C-Jun N-terminal kinase, mitogen activated protein kinase(MAPK) and other signaling pathways and transcriptional regulators are involved in regulating Schwann cell-mediated repair process. This review discusses the main signaling pathways and transcriptional regulators of Schwann cell promoting peripheral nerve regeneration.

Key words: peripheral nerve, Schwann cells, signal pathway, nerve regeneration, repair mechanism

CLC Number:

YANG Yi-duo, GUO Hai-dong, SHAO Shui-jin, LIU Yu-pu. Research progress on mechanism of Schwann cells promoting peripheral nerve regeneration[J]. Basic & Clinical Medicine, 2022, 42(1): 145-148.

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