关键词: 心力衰竭, 血管紧张素Ⅱ, 细胞凋亡, Bax, Bcl-2

Abstract: Objective Observation of losartan heart failure myocardial apoptosis degree of influence,Methods 8-week-old male election SD rats were divided into control group（group C）, heart failure（group HF） and treatment group(group LS)。Use of doxorubicin injection model,group LS at the same time in a row to the oral losartan，TEM myocardial ultrastructure, serum CPK, CK-MB and LDH levels。DNA-situ terminal labeling (TUNEL method) was used to detect myocardial apoptosis, was detected by immunohistochemistry myocardial Bax,Bcl-2 protein expression. The Results group HF than the group C, myocardial cell injury obviously, and apoptotic bodies can be seen, serum CPK, CK-MB and increased LDH,group LS than the group HF, myocardial apoptosis index lower (P <0.01), myocardial cells Bc1-2 expression, Bax expression reduction.Conclusion Losartan can effectively inhibit the process of heart failure occurred in cardiomyocyte apoptosis, reversal of myocardial damage and improve the process of the role of heart failure.

Key words: heart failure, Angiotensin Ⅱ, apoptosis, Bax, Bcl-2