MCP-1在腰椎间盘突出症髓核中的表达及临床意义

基础医学与临床 ›› 2011, Vol. 31 ›› Issue (2): 139-143.

MCP-1在腰椎间盘突出症髓核中的表达及临床意义

郑力峰,叶君健

福建医科大学附属第一医院

收稿日期:2010-01-14 修回日期:2010-05-17 出版日期:2011-02-05 发布日期:2011-03-14
通讯作者: 叶君健 E-mail:yejunjian@medmail.com.cn

Expression and clinical significance of monocyte chemoattractant protein-1 in lumbar disc herniation

ZHENG Li-feng ,YE Jun-Jian

the First Affiliated Hospital of Fujian Medical University

Received:2010-01-14 Revised:2010-05-17 Online:2011-02-05 Published:2011-03-14
Contact: YE Jun-Jian E-mail:yejunjian@medmail.com.cn

摘要/Abstract

摘要： 目的研究单核细胞趋化蛋白-1（MCP-1）在突出的腰椎间盘髓核组织中的表达及其临床意义。方法应用半定量RT-PCR和免疫组织化学法检测48例突出的腰椎间盘（实验组）和10例正常腰椎间盘（对照组）髓核组织中MCP-1信使核糖核酸（mRNA）和蛋白的表达。结果 MCP-1在实验组中的表达明显高于对照组（P<0.01）；在实验组中，后外层纤维环破裂型MCP-1的表达明显高于后外层纤维环完整型（P<0.01）。结论在腰椎间盘突出症的病理生理过程中，MCP-1可能是一个重要的炎症调节因子，在突出的椎间盘组织周围炎症反应中发挥重要的始动作用。

Abstract: Objective To investigate the expression and clinical signficance of monocyte chemoattractant protein-1(MCP-1) in nucleus pulposus of herniated lumbar discs. Methods The mRNA and protein expression of MCP-1 in the experimental group(48 fresh nucleus pulposus of patients with lumbar disc herniation)and control group(10 fresh nucleus pulposus of patients with traumatic lumbar vertebrae)were detected by semi-quantitative RT-PCR and immunohistochemical staining . Results (1)MCP-1 were overexpressed in LDH group compare with those in control group (P<0.01).In different types of herniation,the expression of MCP-1 were higher in external anulus rupture type as compared with that in external anulus intact type (P<0.01).Conclusion MCP-1 maybe an important regulatory factor in inflammatory changes of the herniated lumbar disc,it may play an initial role in the inflammatory reaction around the herniated discs.

郑力峰叶君健. MCP-1在腰椎间盘突出症髓核中的表达及临床意义 [J]. 基础医学与临床, 2011, 31(2): 139-143.

ZHENG Li-feng YE Jun-Jian. Expression and clinical significance of monocyte chemoattractant protein-1 in lumbar disc herniation[J]. Basic & Clinical Medicine, 2011, 31(2): 139-143.