基础医学与临床 ›› 2008, Vol. 28 ›› Issue (4): 360-363.

• 研究论文 • 上一篇    下一篇

参红胶囊联合化疗药物提高中晚期肿瘤病人疗效

黄爱强 叶海红 梁水庭 黄顺荣 蓝碧洋 秦千子   

  1. 中山大学中山医学院 广西民族医院 广西医科大学附属医院 广西肿瘤医院 广西自治区人民医院 广西自治区人民医院
  • 收稿日期:2007-12-24 修回日期:2008-01-18 出版日期:2008-04-25 发布日期:2008-04-25
  • 通讯作者: 黄爱强

Shenhong combinged with chemotherapeutic drugs improved the curative effect on metaphase and terminal cancer patients

Ai-qiang HUANG, Hai-hong YE, Shui-ting LIANG, Shun-rong HUANG, Bi-yang LAN, Qian-zi QIN   

  1. Sun Yet-Sen medical college, Zhongshan University
  • Received:2007-12-24 Revised:2008-01-18 Online:2008-04-25 Published:2008-04-25
  • Contact: Ai-qiang HUANG,

摘要: 目的 观察参红胶囊联合化疗药物对中晚期肿瘤病人疗效、症状改善和免疫功能影响。方法 将598例确诊肿瘤患者随机分为两组,205例单纯使用化疗组,393例参红胶囊加化疗组。连续治疗60d后,观察疗效、症状改善情况、卡氏评分、免疫功能、外周血白细胞计数等。结果 与对照组相比,参红胶囊组肿瘤患者总缓解率42.0%;疼痛、咳嗽、乏力和食欲不振平均改善率为71.9%;卡氏评分提高27.0%;CD3+、CD4+数量增加11.6 %和19.3 %,CD8+降低22.6%,CD4+/CD8+增加54.2%;NK细胞活性和巨噬细胞功能明显提高,IgG和IgA含量增加。结论 参红胶囊联合化疗提高中晚期恶性肿瘤患者的疗效。这可能与其提高患者免疫功能有关。

关键词: 参红胶囊, 抗肿瘤药, 疗效, Karnofsky评分, 免疫

Abstract: Objective To observe the effects of Shenhong (SH) combined with chemotherapeutic drugs on curative effect, symptoms improvement, and immunology function in 393 metaphase or terminal cancer patients. Methods All 598 patients were divided into two groups. One was the control group that had 205 patients treated with chemotherapeutic drugs. The other one was SH-treated group, which had 393 patients treated with SH combined with chemotherapeutic drugs that were given for 60 days. Then, the data were recorded and analyzed for all cases. Results Compared with control patients, the total remission was 42.0% in SH-treated patients. The improvement rates of pain, cough, debilitation, and anepithymia were 71.9%. The Karnofsky grade was increased by 27.0%. Besides, the CD3+ and CD4+ were increased by 11.6% and 19.3%, but CD8+ was decreased by 22.6% at the same time. The patients CD4+/ CD8+ was enhanced by 54.2%, while the NK cell activity and marophage phagocysis were improved significantly. It was also seen that the content of Ig G and Ig A were increased in the same group. Conclusion It is clear that the curative effect of SH combined with chemotherapeutic drugs were higher than that of chemotherapeutic drugs in the metaphase or terminal cancer patients. The therapeutic effect of SH is regarded as the immunology regulation.

Key words: Shenhong capsule(SH), chemotherapeutic drugs, curative effect, Karnofsky grade, immunology

中图分类号: