γH2AX和ATM与内源性氧化剂所致DNA损伤关系的研究进展

基础医学与临床 ›› 2010, Vol. 30 ›› Issue (4): 437-441.

• 短篇综述 • 上一篇

γH2AX和ATM与内源性氧化剂所致DNA损伤关系的研究进展

赵晋郭忠马建秀

西北民族大学医学院西北民族大学医学院西北民族大学医学院

收稿日期:2009-06-08 修回日期:2009-08-24 出版日期:2010-04-05 发布日期:2010-04-05
通讯作者: 赵晋

Research about the relationship between γH2AX, ATM and DNA damage by endogenous oxidants

Jin ZHAO, Zhong GUO, Jian-xiu MA

Medical College of Northwest University for Minorities Medical College of Northwest University for Minorities

Received:2009-06-08 Revised:2009-08-24 Online:2010-04-05 Published:2010-04-05
Contact: Jin ZHAO,

摘要/Abstract

摘要： 本文综述了正常细胞及肿瘤细胞系中内源性氧化剂所致的磷酸化ATM (CAA) 和γH2AX (CHP)的形成与表达；同时综述了各种影响因子和生长条件对CAA和CHP表达的影响。

关键词: 内源性氧化剂, γH2AX, ATM

Abstract: This review describes the observations that constitutive ATM activation (CAA) and H2AX phosphorylation (CHP) take place caused by endogenous oxidants in normal cells as well in tumor cell lines. This review also presents the findings on differences in CAA and CHP on the effects of several agents and growth conditions.

Key words: endogenous oxidants, γH2AX, ATM

中图分类号:

R730

赵晋郭忠马建秀. γH2AX和ATM与内源性氧化剂所致DNA损伤关系的研究进展[J]. 基础医学与临床, 2010, 30(4): 437-441.

Jin ZHAO; Zhong GUO; Jian-xiu MA. Research about the relationship between γH2AX, ATM and DNA damage by endogenous oxidants[J]. Basic & Clinical Medicine, 2010, 30(4): 437-441.

γH2AX和ATM与内源性氧化剂所致DNA损伤关系的研究进展

Research about the relationship between γH2AX, ATM and DNA damage by endogenous oxidants

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