丝裂原活化的蛋白激酶通路与吗啡耐受

基础医学与临床 ›› 2010, Vol. 30 ›› Issue (3): 325-328.

丝裂原活化的蛋白激酶通路与吗啡耐受

张颜波孙保亮袁慧杨明峰牛敬忠吕国蔚

泰山医学院附属医院泰山医学院附属医院神经内科泰山医学院附属医院神经内科首都医科大学低氧医学研究所

收稿日期:2009-04-03 修回日期:2009-07-07 出版日期:2010-03-05 发布日期:2011-05-04
通讯作者: 吕国蔚

Mitogen-activated protein kinases and morphine tolerance

Yan-bo ZHANG, Bao-liang SUN, Hui YUAN, Ming-feng YANG, Jing-zhong NIU, Guo-wei LV

the Affiliated Hospital of Tai Shan Medical College Institute for Hypoxia Medicine, Capital Medical University

Received:2009-04-03 Revised:2009-07-07 Online:2010-03-05 Published:2011-05-04
Contact: Guo-wei LV

摘要/Abstract

摘要： MAPKs激活通路包括3个被顺序激活的蛋白激酶：MAPKs激酶的激酶（MKKKs）→MAPKs激酶（MKKs）→MAPKs；有MAPK细胞外信号调节激酶（MAPKERK）、c-Jun 氨基末端激酶（MAPKJNK）、MAPKP38和MKK5/MAPKERK5 等4条通路。吗啡耐受后，MAPKs（ERK、JNK和P38）激活增加。MAPKs激活通路上每个环节的抑制剂，均是临床上治疗吗啡耐受的潜在药物。

关键词: 丝裂原活化的蛋白激酶, 吗啡耐受, MAPKs抑制剂

Abstract: The MAPKs activation pathway consists of three protein kinases in activation sequence: MAPKs kinase kinases (MKKKs) →MAPKs kinases (MKKs) →MAPKs and four pathways:extracellular signal-regulated kinase (MAPKERK), c-Jun N-terminal kinase (MAPKJNK), MAPKP38 and MKK5/MAPKERK5 activation pathways.It has been proved that MAPKs(ERK,JNK and P38) are acvtivated in the progress of morphine tolerance. Inhibitors of each and every element of MAPKs activation pathway are promising clinical drugs for morphine tolerance.

Key words: mitogen-activated proteins kinases, morphine tolerance, MAPKs inhibitiors

中图分类号:

Q42，R969.3

张颜波孙保亮袁慧杨明峰牛敬忠吕国蔚. 丝裂原活化的蛋白激酶通路与吗啡耐受[J]. 基础医学与临床, 2010, 30(3): 325-328.

Yan-bo ZHANG; Bao-liang SUN; Hui YUAN; Ming-feng YANG; Jing-zhong NIU; Guo-wei LV. Mitogen-activated protein kinases and morphine tolerance[J]. Basic & Clinical Medicine, 2010, 30(3): 325-328.