关键词: Wnt, β-连环蛋白, 信号途径, 肾脏疾病

Abstract: Wnt/β-catenin signaling pathway is involved in kidney development and many kidney diseases, including kidney cancers, renal fibrosis, Polycystic kidney disease, acute renal failure and diabetic nephropathy. The pathway control ureteric bud development and regulate nephrogenesis in the mesenchcymal cells ；It also plays a critical role in the oncogenesis and progression of many kidney cancers; Aberrantly activation of Wnt/β-catenin signal induces proliferation or apoptosis of glomerular mesangial cells and renal tubular epithelial cells , which leads to pathogenesis of many kidney diseases. These important roles of the Wnt/β-catenin signaling pathway in kidney development and diseases are considerably consered.