关键词: 细胞色素P450酶1A1, 谷胱甘肽S-转硫酶M1, 基因多态性, 肺鳞癌

Abstract: Objective To explore the effect of cytochrome P450 enzyme 1A1(CYP1A1), Glutathione-S-transferase M1(GSTM1) genetic polymorphism and smoking factor on the occurrence of male lung squamous carcinoma. Methods CYP1A1、GSTM1 genotypes were detected with oligonucleotidechip technique in 125 male lung squamous carcinoma patients and 125 healthy controls. Results Frequencies of GG genotype at CYP1A1 m2 site and frequencies of GSTM1 null genotypes were significantly increased in lung cancer group compared to control group (P<0.05). When stratified by smoking status, there were elevated risks for smokers in lung cancer cases carrying at least one G allele of CYP1A1 m2 site or GSTM1 null genotype, the odds ratios were 4.50 or 3.18 respectively (P<0.01). Conclusion CYP1A1 and GSTM1 gene polymorphism were associated with the occurrence of male lung squamous cell carcinoma, smoking factors and CYP1A1、GSTM1 polymorphism have a synergistic effect.

Key words: Cytochrome P450 enzyme 1A1, Glutathione-S-transferase M1, Gene polymorphisms, Lung squamous carcinoma