关键词: 肾功能衰竭, 毛霉菌病

Abstract: Objective To investigate clinical characteristics, diagnosis, treatment and prognosis of mucormycosis in patients with renal failure. Mathods We reported a case of mucormycosis in a 65-year old man with chronic renal failure and treated successfully with amphotericin B. And cases of mucormycosis complicated with renal failure reported in literatures were reviewed excluding mucormycosis peritonitis associated with peritoneal dialysis and desferrioxamine-related mucormycosis. Results Fifteen cases including our case were involved with mean age of 49.87 15.84 years old. Rhinocerebral, pulmonary, and disseminated forms accounted for 46.7%, 33.3% and 20% respectively. Postmortem diagnosis was made in 46.7% of patients. Mortality rate was 73.3% in all of them and 42.9% in seven patients who received antifungal therapy. No one was survival in patients without treatments. Conclusion Mucormycosis is a lethal invasive infection in patients with renal failure. The important management to improve prognosis are early diagnosis, surgical debridement, drainage and aggressive antifungal therapy.

Key words: renal failure, Mucormycosis