泛凋亡在年龄相关性疾病中的研究进展

doi:10.16352/j.issn.1001-6325.2025.11.1506

基础医学与临床 ›› 2025, Vol. 45 ›› Issue (11): 1506-1510.doi: 10.16352/j.issn.1001-6325.2025.11.1506

泛凋亡在年龄相关性疾病中的研究进展

张越, 王君影^*

大连大学附属新华医院耳鼻咽喉科,辽宁大连 116021

收稿日期:2025-01-10 修回日期:2025-03-25 出版日期:2025-11-05 发布日期:2025-10-24
通讯作者: ^*77044636@qq.com
基金资助:
辽宁省教育厅面上项目(LJKZ1193)

Progress of PANoptosis in age-related diseases

ZHANG Yue, WANG Junying^*

Department of Otolaryngology,Xinhua Hospital Affiliated to Dalian University,Dalian 116021,China

Received:2025-01-10 Revised:2025-03-25 Online:2025-11-05 Published:2025-10-24
Contact: ^*77044636@qq.com

摘要/Abstract

摘要： 泛凋亡(PANoptosis)是通过形成泛凋亡小体(PANoptosome),智能启动信号通路的新型细胞死亡模式。它能通过调控高血糖引发的炎性反应和细胞死亡,促进视网膜病变和肾病的发生。能激活炎性小体释放,在阿尔茨海默病(AD)和骨关节炎中发挥作用。类似地, 泛凋亡可通过损伤线粒体、改变免疫反应及引发炎性反应,促进耳蜗的衰老,为疾病提供新的治疗思路。

关键词: 细胞死亡, 泛凋亡, 年龄相关

Abstract: PANoptosis is a novel mode of cell death that intelligently initiates signaling pathways by forming PANoptosome. It can promote the development of retinopathy and nephropathy by regulating the inflammatory response and cell death triggered by hyperglycemia. It activates inflammasome release and plays a role in Alzheimer's disease (AD) and osteoarthritis. Similarly,PANoptosis can promote cochlear aging by damaging mitochondria, changing immune response and inducing inflammatory response, aiming to provide new therapeutic ideas for the disease.

Key words: cell death, PANoptosis, age-related

中图分类号:

张越, 王君影. 泛凋亡在年龄相关性疾病中的研究进展[J]. 基础医学与临床, 2025, 45(11): 1506-1510.

ZHANG Yue, WANG Junying. Progress of PANoptosis in age-related diseases[J]. Basic & Clinical Medicine, 2025, 45(11): 1506-1510.

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泛凋亡在年龄相关性疾病中的研究进展

Progress of PANoptosis in age-related diseases

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