T淋巴细胞亚群在普通型与难治性支原体肺炎中的分布差异及其对治疗的影响

doi:10.16352/j.issn.1001-6325.2025.10.1313

基础医学与临床 ›› 2025, Vol. 45 ›› Issue (10): 1313-1317.doi: 10.16352/j.issn.1001-6325.2025.10.1313

T淋巴细胞亚群在普通型与难治性支原体肺炎中的分布差异及其对治疗的影响

朱琳¹, 付书琴², 贾婉玉¹, 郭彩丽¹, 宋春兰^1*

郑州大学附属儿童医院河南省儿童医院郑州儿童医院 1. 南区急诊综合病房; 2. 南区急诊科, 河南郑州 450000

收稿日期:2024-09-24 修回日期:2024-12-31 出版日期:2025-10-05 发布日期:2025-09-22
通讯作者: ^*13526867323@163.com
基金资助:
2022年度河南省医学科技攻关计划联合共建项目(LHGJ20220734)

Distribution difference of T lymphocyte subsets in common and refractory mycoplasma pneumonia and its impact on clinical treatment

ZHU Lin¹, FU Shuqin², JIA Wanyu¹, GUO Caili¹, SONG Chunlan^1*

1. South Comprehensive Ward; 2. South Emergency Department, Zhengzhou University Affiliated Children's Hospital, Henan Children's Hospital, Zhengzhou Children's Hospital,Zhengzhou 450000, China

Received:2024-09-24 Revised:2024-12-31 Online:2025-10-05 Published:2025-09-22
Contact: ^*13526867323@163.com

摘要/Abstract

摘要： 目的探讨T淋巴细胞亚群在普通型与难治性支原体肺炎中的分布差异及其对治疗的影响。方法回顾性选取2023年10月至2024年1月于郑州儿童医院就诊的200例支原体肺炎患儿,按照病情严重程度和治疗情况分为普通型支原体肺炎组、难治性支原体肺炎组,各100例。对比普通型支原体肺炎与难治性支原体肺炎T细胞免疫表型CD4⁺、CD8⁺、CD4⁺/CD8⁺的分布;分析CD4⁺、CD8⁺、CD4⁺/CD8⁺及联合检测预测难治性支原体肺炎发生的效能。结果相较于普通型支原体肺炎组,难治性支原体肺炎组学龄期患儿比例更高,热程和住院时间更长(P＜0.05)。相较于普通型支原体肺炎组,难治性支原体肺炎组CD4⁺表达轻微下降,但两组比较无统计学意义,CD8⁺表达明显升高(P＜0.05),CD4⁺/CD8⁺表达明显下降(P＜0.05)。受试者工作特征曲线(ROC)显示,CD4⁺(AUC=0.532,95% CI=0.455～0.608)、CD8⁺(AUC=0.592,95% CI=0.515～0.666)、CD4⁺/CD8⁺(AUC=0.579,95% CI=0.502～0.653)及联合检测(AUC=0.607,95% CI=0.531～0.680)。结论和普通型支原体肺炎组相比,难治性支原体肺炎组CD4⁺表达轻微下降,CD8⁺表达明显升高,CD4⁺/CD8⁺表达明显下降,上述指标在预测难治性支原体肺炎的发生上均具有一定价值,联合预测价值更高。

关键词: 支原体肺炎, 普通型支原体肺炎, 难治性支原体肺炎, CD4⁺T淋巴细胞, CD8⁺T淋巴细胞

Abstract: Objective To investigate the distribution difference of T lymphocyte subsets in common and refractory mycoplasma pneumonia and its impact on treatment. Methods Two hundred children with mycoplasma pneumonia hospitalized from October 2023 to January 2024 were retrospectively reviewed and divided into common mycoplasma pneumonia group and refractory mycoplasma pneumonia group (n=100 each) according to the severity of disease and treatment. The distribution of T cell immunophenotypes CD4⁺, CD8⁺ and CD4⁺/CD8⁺ were compared between common mycoplasma pneumonia and refractory mycoplasma pneumonia. The predictive value of CD4⁺, CD8⁺ counting, CD4⁺/CD8⁺ and combined detection on the occurrence of refractory mycoplasma pneumonia were analyzed. Results Compared with the common mycoplasma pneumonia group, the refractory mycoplasma pneumonia group had more school-age children, longer fever duration and hospital stay (P＜0.05). Compared with the common mycoplasma pneumonia group, CD4⁺ expression was slightly decreased in the refractory mycoplasma pneumonia group, but there was no statistical significance between the two groups;CD8⁺ expression was significantly increased while CD4⁺/CD8⁺ expression was significantly decreased (P＜0.05). Receiver operating characteristic curve (ROC) showed that CD4⁺ (AUC=0.532, 95% CI=0.455-0.608), CD8⁺ (AUC=0.592, 95% CI=0.515-0.666), CD4⁺/CD8⁺ (AUC=0.579, 95% CI=0.502-0.653) and combined detection (AUC=0.607, 95% CI=0.531-0.680). Conclusions Compared with the common mycoplasma pneumonia group, CD4⁺ expression is slightly decreased, CD8⁺ expression is significantly increased, and CD4⁺/CD8⁺ expression is significantly decreased in the refractory mycoplasma pneumonia group. All these indicators hold certain value in predicting the occurrence of refractory mycoplasma pneumonia, with combined detection demonstrating higher predictive value.

Key words: mycoplasma pneumonia, common mycoplasma pneumonia, refractory mycoplasma pneumonia, CD4⁺T lymphocytes, CD8⁺T lymphocytes

中图分类号:

R725.6

朱琳, 付书琴, 贾婉玉, 郭彩丽, 宋春兰. T淋巴细胞亚群在普通型与难治性支原体肺炎中的分布差异及其对治疗的影响[J]. 基础医学与临床, 2025, 45(10): 1313-1317.

ZHU Lin, FU Shuqin, JIA Wanyu, GUO Caili, SONG Chunlan. Distribution difference of T lymphocyte subsets in common and refractory mycoplasma pneumonia and its impact on clinical treatment[J]. Basic & Clinical Medicine, 2025, 45(10): 1313-1317.

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T淋巴细胞亚群在普通型与难治性支原体肺炎中的分布差异及其对治疗的影响

Distribution difference of T lymphocyte subsets in common and refractory mycoplasma pneumonia and its impact on clinical treatment

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