低氧诱导因子-1α在肌肉减少症发病中作用机制

doi:10.16352/j.issn.1001-6325.2025.08.1093

基础医学与临床 ›› 2025, Vol. 45 ›› Issue (8): 1093-1097.doi: 10.16352/j.issn.1001-6325.2025.08.1093

低氧诱导因子-1α在肌肉减少症发病中作用机制

朱启海, 张俣^*

新疆医科大学第五附属医院呼吸与危重症医学科,新疆乌鲁木齐 830000

收稿日期:2025-02-18 修回日期:2025-05-06 出版日期:2025-08-05 发布日期:2025-07-11
通讯作者: ^*hxzy85425@163.com
基金资助:
新疆维吾尔自治区自然科学基金(2023D01C153)

The role of hypoxia-inducible factor-1α in the pathogenesis of sarcopenia

ZHU Qihai, ZHANG Yu^*

Department of Respiratory and Critical Care Medicine, the Fifth Affiliated Hospital of Xinjiang Medical University, Urumqi 830000, China

Received:2025-02-18 Revised:2025-05-06 Online:2025-08-05 Published:2025-07-11
Contact: ^*hxzy85425@163.com

摘要/Abstract

摘要： HIF-1α作为细胞适应低氧的关键转录因子,在肌少症发生发展中扮演重要角色。长期慢性低氧环境下,HIF-1α表达水平异常,通过调控铁代谢、线粒体功能、血管生成、细胞外基质重塑、蛋白合成与代谢等多条信号通路参与肌少症的发生发展。此外,HIF-1α的过度激活会导致卫星细胞功能障碍,降低肌肉再生和修复的能力。

关键词: 低氧诱导因子-1α, 肌少症, 发病机制

Abstract: HIF-1α, a key transcription factor for cellular adaptation to hypoxia, plays a significant role in the development of sarcopenia. In the context of long-term chronic hypoxia, the expression level of HIF-1α is abnormal. It functions in the development of sarcopenia by regulating multiple signaling pathways, including iron metabolism, mitochondrial function, angiogenesis, remodeling of the extracellular matrix, and protein synthesis and metabolism. Moreover, the overactivation of HIF-1α may lead to dysfunction of satellite cells, thereby reducing the capacity for muscle regeneration and repair.

Key words: hypoxia inducible factor-1α, sarcopenia, pathogenesis

中图分类号:

R587.1

朱启海, 张俣. 低氧诱导因子-1α在肌肉减少症发病中作用机制[J]. 基础医学与临床, 2025, 45(8): 1093-1097.

ZHU Qihai, ZHANG Yu. The role of hypoxia-inducible factor-1α in the pathogenesis of sarcopenia[J]. Basic & Clinical Medicine, 2025, 45(8): 1093-1097.

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低氧诱导因子-1α在肌肉减少症发病中作用机制

The role of hypoxia-inducible factor-1α in the pathogenesis of sarcopenia

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