子宫腺肌症孕妇血清EGFR、CA125水平与妊娠结局相关

doi:10.16352/j.issn.1001-6325.2025.05.0658

基础医学与临床 ›› 2025, Vol. 45 ›› Issue (5): 658-663.doi: 10.16352/j.issn.1001-6325.2025.05.0658

子宫腺肌症孕妇血清EGFR、CA125水平与妊娠结局相关

张雪¹, 王纪元¹, 高双霞², 郭战坤³, 李静⁴, 索青霞^1*

保定市妇幼保健院 1.妇产科; 4.产科,河北保定 071000; 2.涿州市妇幼保健院妇产科,河北涿州 072750; 3.保定市第三中心医院妇产科,河北保定 071051

收稿日期:2024-07-15 修回日期:2024-11-01 出版日期:2025-05-05 发布日期:2025-04-23
通讯作者: ^* baodingfuyousuo@163.com
基金资助:
保定市科技计划(17ZF116)

Serum EGFR and CA125 levels are correlated in women with adenomyosis pregnancy outcomes

ZHANG Xue¹, WANG Jiyuan¹, GAO Shuangxia², GUO Zhankun³, LI Jing⁴, SUO Qingxia^1*

1. Department of Obstetrics and Gynecology; 4. Department of Obstetrics, Baoding Maternal and Child Health Hospital, Baoding 071000; 2. Department of Obstetrics and Gynecology, Zhuozhou Maternal and Child Health Hospital, Zhuozhou 072750; 3. Department of Obstetrics and Gynecology, Baoding Third Central Hospital, Baoding 071051, China

Received:2024-07-15 Revised:2024-11-01 Online:2025-05-05 Published:2025-04-23
Contact: ^* baodingfuyousuo@163.com

摘要/Abstract

摘要： 目的探讨子宫腺肌症(AM)孕妇血清表皮生长因子受体(EGFR)、癌抗原125(CA125)水平变化及其与妊娠结局的关系。方法选取保定市妇幼保健院于2021年6月至2023年8月期间收治的108例患有AM的孕妇(AM孕妇组),依据妊娠结局情况分为妊娠良好组(n=43)和妊娠不良组(n=65)。另选取同期AM患者作为AM组、同期108例孕检正常的孕妇作为对照组。ELISA检测血清中EGFR、CA125水平。用Pearson相关性分析AM孕妇血清EGFR与CA125的相关性。用多因素Logistic回归分析AM妊娠结局的影响因素;用受试者工作特征(ROC)曲线分析血清EGFR、CA125水平对AM妊娠结局的预测价值。结果与对照组相比,AM组、AM孕妇组血清EGFR、CA125水平均明显升高,AM孕妇组血清EGFR、CA125水平均高于AM组(P＜0.05)。随着内膜侵入肌层深度分级增加血清EGFR、CA125水平依次升高;血清EGFR、CA125水平在弥漫型、增殖期明显升高(P＜0.05)。胎膜早破、早产、前置胎盘和流产的AM孕妇血清中EGFR、CA125水平明显升高(P＜0.05)。经Pearson相关性分析显示,AM孕妇血清EGFR与CA125呈显著正相关(r=0.487,P＜0.05)。妊娠良好组血清EGFR、CA125水平低于妊娠不良组(P＜0.05)。血清EGFR、CA125及二者联合预测AM妊娠结局的曲线下面积(AUC)分别为0.880、0.835及0.955,二者联合预测AM妊娠结局的AUC显著高于血清EGFR、CA125单独预测(Z_{二者联合-EGFR}=2.279、Z_{二者联合-CA125}=3.304,均P＜0.05)。结论 AM孕妇血清EGFR、CA125水平升高,与妊娠结局密切相关,均是影响AM妊娠不良的危险因素,且二者联合预测AM妊娠结局的效能更佳。

关键词: 子宫腺肌症, 表皮生长因子受体, 癌抗原125, 妊娠结局

Abstract: Objective To explore the changes in serum epidermal growth factor receptor (EGFR) and cancer antigen 125 (CA125) levels in pregnant women with adenomyosis (AM) and their relationship with pregnancy outcomes. Methods A total of 108 pregnant women with AM(AM pregnant women group) admitted to Baoding Maternal And Child Health Hospital from June 2021 to August 2023 were collected and divided into a good pregnancy group (n=43) and a poor pregnancy group (n=65) based on pregnancy outcomes. Meanwhile, AM patients were selected as AM group and 108 pregnant women with normal pregnancy test were selected as control group. ELISA was applied to detect the serum level of EGFR and CA125. Pearson correlation was applied to analyze the correlation between serum EGFR and CA125 in AM pregnant women. Multivariate logistic regression was applied to analyze the factors that affected the outcome of AM pregnancy. Receiver operating characteristic (ROC) curve was applied to analyze the predictive value of serum EGFR and CA125 levels for AM pregnancy outcomes. Results Compared with the control group, serum level of EGFR and CA125 in AM group and AM pregnant women group were significantly increased and serum level of EGFR and CA125 in AM pregnant women group was higher than that in AM group (P＜0.05). As the depth grading of endometrial invasion increased, serum level of EGFR and CA125 increased sequentially; The serum level of EGFR and CA125 was obviously elevated in diffuse type and proliferate phase (P＜0.05). The expression level of EGFR and CA125 in the serum of AM pregnant women with premature rupture of membranes, premature birth, placenta previa, and miscarriage was significantly increased(P＜0.05). According to Pearson correlation analysis, there was a positive correlation between serum EGFR and CA125 in AM pregnant women (r=0.487, P＜0.05). The serum level of EGFR and CA125 in good pregnancy group was lower than that in poor pregnancy group (P＜0.05). The area under the curve (AUC) of serum EGFR, CA125, and their combined prediction for AM pregnancy outcome was 0.880, 0.835, and 0.955, respectively and the combined prediction of AUC for AM pregnancy outcome was significantly higher than that of serum EGFR and CA125 alone prediction (Z_{combination-EGFR}=2.279, Z_{combination-CA125}=3.304, both P＜0.05). Conclusions Serum level of EGFR and CA125 in AM pregnant women is elevated, which is closely related to pregnancy outcomes and is potential risk factor for poor pregnancy in AM. The combination of the two is more effective in predicting pregnancy outcomes in AM.

Key words: adenomyosis, epidermal growth factor receptor, cancer antigen 125, pregnancy outcome

中图分类号:

R714.2

张雪, 王纪元, 高双霞, 郭战坤, 李静, 索青霞. 子宫腺肌症孕妇血清EGFR、CA125水平与妊娠结局相关[J]. 基础医学与临床, 2025, 45(5): 658-663.

ZHANG Xue, WANG Jiyuan, GAO Shuangxia, GUO Zhankun, LI Jing, SUO Qingxia. Serum EGFR and CA125 levels are correlated in women with adenomyosis pregnancy outcomes[J]. Basic & Clinical Medicine, 2025, 45(5): 658-663.

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子宫腺肌症孕妇血清EGFR、CA125水平与妊娠结局相关

Serum EGFR and CA125 levels are correlated in women with adenomyosis pregnancy outcomes

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