肠道菌群代谢物次级胆汁酸调控宿主免疫功能

doi:10.16352/j.issn.1001-6325.2024.06.0887

基础医学与临床 ›› 2024, Vol. 44 ›› Issue (6): 887-891.doi: 10.16352/j.issn.1001-6325.2024.06.0887

肠道菌群代谢物次级胆汁酸调控宿主免疫功能

岳玲玲, 王梓潓, 李小芹, 李利锋, 张万存, 于志丹^*

郑州大学附属儿童医院河南省儿童医院郑州儿童医院郑州市儿童消化疾病重点实验室,河南郑州 450018

收稿日期:2023-09-15 修回日期:2024-01-23 出版日期:2024-06-05 发布日期:2024-05-24
通讯作者: ^*zhidanyu2013@126.com
基金资助:
国家自然科学基金(81903330);河南省科技攻关(202102310071);河南省医学科技攻关(SBGJ202303047)

Regulation of host immune function by gut microbiota-derived secondary bile acids

YUE Lingling, WANG Zihui, LI Xiaoqin, LI Lifeng, ZHANG Wancun, YU Zhidan^*

Zhengzhou Key Laboratory of Children's Digestive Diseases, Henan Children's Hospital Zhengzhou Children's Hospital, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou 450018, China

Received:2023-09-15 Revised:2024-01-23 Online:2024-06-05 Published:2024-05-24
Contact: ^*zhidanyu2013@126.com

摘要/Abstract

摘要： 肠道菌群紊乱破坏宿主免疫系统的平衡。肠道菌群代谢产生许多与宿主相互作用的生物活性分子,典型代表是次级胆汁酸(SBAs)。SBAs通过结合膜受体和核受体,例如武田G蛋白偶联受体5(TGR5)和法尼醇X受体(FXR),参与调控能量代谢和炎性反应相关基因的表达,对维持宿主免疫稳态具有重要意义。

关键词: 肠道菌群, 次级胆汁酸, 免疫调控

Abstract: Disturbances of gut microbiota may affect the balance of the host immune system. The metabolism of gut microbiota produces many bioactive molecules interacting with host, typically secondary bile acids (SBAs). SBAs are involved in regulating the energy metabolism and the expression of inflammatory response-related genes by binding to membrane receptors and nuclear receptors, such as takeda G protein-coupled receptor (TGR5) and farnesol X receptor (FXR), which are essential for maintaining host immune homeostasis.

Key words: gut microbiota, secondary bile acids, immune regulation

中图分类号:

R392.32

岳玲玲, 王梓潓, 李小芹, 李利锋, 张万存, 于志丹. 肠道菌群代谢物次级胆汁酸调控宿主免疫功能[J]. 基础医学与临床, 2024, 44(6): 887-891.

YUE Lingling, WANG Zihui, LI Xiaoqin, LI Lifeng, ZHANG Wancun, YU Zhidan. Regulation of host immune function by gut microbiota-derived secondary bile acids[J]. Basic & Clinical Medicine, 2024, 44(6): 887-891.

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肠道菌群代谢物次级胆汁酸调控宿主免疫功能

Regulation of host immune function by gut microbiota-derived secondary bile acids

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