基础医学与临床 ›› 2024, Vol. 44 ›› Issue (6): 748-752.doi: 10.16352/j.issn.1001-6325.2024.06.0748

• 特邀专题:肾上腺肿瘤的发病机制 • 上一篇    下一篇

肾上腺皮质癌基因及分子机制

刘晶华, 卢琳*   

  1. 中国医学科学院 北京协和医学院 北京协和医院 内分泌科 国家卫生健康委员会内分泌重点实验室,北京 100730
  • 收稿日期:2024-03-31 修回日期:2024-04-25 出版日期:2024-06-05 发布日期:2024-05-24
  • 通讯作者: *lulin88@sina.com
  • 基金资助:
    国家重点研发计划项目常见多发病防治研究专项 (2022YFC2505300, 子课题: 2022YFC2505304)

Genetic and molecular mechanism changes of adrenocortical carcinoma

LIU Jinghua, LU Lin*   

  1. Department of Endocrinology, Key Laboratory of Endocrinology of National Health Commission, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China
  • Received:2024-03-31 Revised:2024-04-25 Online:2024-06-05 Published:2024-05-24
  • Contact: *lulin88@sina.com

摘要: 肾上腺皮质癌(ACC)是一种罕见的肿瘤,部分可具有分泌类固醇激素的功能,其整体预后不良,尤其是对于难以手术切除的转移ACC患者,临床诊治存在挑战。现有研究表明ACC发病机制复杂,在肾上腺皮质生发及稳态维持中的分子水平改变均可能与疾病的产生相关。本文回顾近年来的研究,从肾上腺皮质的正常发育过程、多组学研究等,总结在此过程中目前可能与ACC相关的基因和分子机制,包括基因改变、表观遗传学改变、非编码RNA差异、免疫微环境及基于多组学分析发现的特征,从而为后续治疗靶点的选择提供依据。

关键词: 肾上腺皮质癌, 肾上腺皮质发育, 分子机制, 多组学研究

Abstract: Adreno-cortical carcinoma (ACC) is an uncommon tumor, some of them may produce excessive steroid hormone. The prognosis of ACC is quite poor and current treatment options are relatively limited, especially for patients whose tumor is metastatic and difficult to remove by surgical operation. This makes the management of ACC challenging. Existing studies have shown that the mechanisms of ACC are complex. The molecular changes happen in adrenocortical development and homeostasis may explain the occurrence of ACC. This review focuses on recent studies and summarizes the genetic and molecular mechanism changes that potentially associated with ACC in the development process of the adrenal cortex and multi-omics studies, including genomic changes, epigenetic changes, differences in non-coding RNA, immune microenvironment and features found through multi-omics analysis. This information may support screening of therapeutic targets of ACC in future.

Key words: adrenocortical carcinoma, adrenocortical development, molecular mechanism, multiple omics studies

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