基础医学与临床 ›› 2024, Vol. 44 ›› Issue (4): 544-547.doi: 10.16352/j.issn.1001-6325.2024.04.0544

• 短篇综述 • 上一篇    下一篇

血管生成素样蛋白8在心血管疾病发病中作用的研究进展

韩丽杰, 胡朝伟, 于华惠, 秦彦文*   

  1. 首都医科大学附属北京安贞医院 心血管重塑相关疾病教育部重点实验室,北京 100029
  • 收稿日期:2023-08-10 修回日期:2024-01-18 出版日期:2024-04-05 发布日期:2024-03-25
  • 通讯作者: *qinyanwen@vip.126.com
  • 基金资助:
    国家自然科学基金(81970224);国家重点研发计划(2021YFC2500600;2021YFC2500603)

Research progress on the roles of angiopoietin-like protein 8 in the pathogenesis of cardiovascular diseases

HAN Lijie, HU Chaowei, YU Huahui, QIN Yanwen*   

  1. The Key Laboratory of Cardiovascular Remodeling-related Diseases, Ministry of Education, Beijing Anzhen Hospital,Capital Medical University, Beijing 100029, China
  • Received:2023-08-10 Revised:2024-01-18 Online:2024-04-05 Published:2024-03-25
  • Contact: *qinyanwen@vip.126.com

摘要: 血管生成素样蛋白8(ANGPTL8)是由肝脏和脂肪组织合成、分泌的一种糖蛋白,能够促进血管重塑、调节炎性反应,并通过这些机制参与冠心病、高血压、主动脉瘤、病理性心肌肥厚等多种心血管疾病的发生与发展,有望成为心血管疾病新的预防和治疗靶点。

关键词: 血管生成素样蛋白8, 冠心病, 高血压, 主动脉瘤, 病理性心肌肥厚

Abstract: Angiopoietin-like protein 8(ANGPTL8) secreted by liver and adipose tissue, is a glycoprotein exerting paramount effects on facilitation of vascular remodeling and regulation of inflammatory response; ANGPTL8 is involved in the initiation and progression of cardiovascular diseases including coronary artery disease, hypertension, aortic aneurysm and pathological cardiac hypertrophy, and holds promise for being a new target for the prevention and treatment of cardiovascular diseases.

Key words: angiopoietin-like protein 8, coronary artery disease, hypertension, aortic aneurysm, pathological cardiac hypertrophy

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