转录因子T-bet在慢性阻塞性肺疾病发病中作用的研究进展

doi:10.16352/j.issn.1001-6325.2023.08.1322

基础医学与临床 ›› 2023, Vol. 43 ›› Issue (8): 1322-1325.doi: 10.16352/j.issn.1001-6325.2023.08.1322

转录因子T-bet在慢性阻塞性肺疾病发病中作用的研究进展

陈瑜婷¹, 黄玲^2*, 夏俊杰², 邱宇², 弋可³, 王金诚⁴

1.西南医科大学临床医学院呼吸与危重症医学科,四川泸州 646000;
2.绵阳市第三人民医院(四川省精神卫生中心)呼吸与危重症学科,四川绵阳 621054;
3.四川省科学城医院呼吸与危重症医学科,四川绵阳 621054;
4.中江县人民医院呼吸与危重症医学科,四川德阳 618199

收稿日期:2022-08-16 修回日期:2022-12-27 出版日期:2023-08-05 发布日期:2023-07-26
通讯作者: ^*1721684460@qq.com
基金资助:
四川省卫生健康科研课题基金(19PJ218)

Research progress on the role of transcription factor T-bet in the pathogenesis of chronic obstructive pulmonary disease

CHEN Yuting¹, HUANG Ling^2*, XIA Junjie², QIU Yu², YI Ke³, WANG Jincheng⁴

1. Department of Respiratory and Critical Care Medicine, Clinical Medical College, Southwest Medical University, Luzhou 646000;
2. Department of Respiratory and Critical Care, the Third People's Hospital of Mianyang (Sichuan Mental Health Center), Mianyang 621054;
3. Department of Respiratory and Critical Care Medicine,Sichuan Science City Hospital, Mianyang 621054;
4. Department of Respiratory and Critical Care Medicine, Zhongjiang County People's Hospital, Deyang 618199, China

Received:2022-08-16 Revised:2022-12-27 Online:2023-08-05 Published:2023-07-26
Contact: ^*1721684460@qq.com

摘要/Abstract

摘要： 慢性阻塞性肺疾病(COPD)是一种慢性进行性发展的呼吸系统疾病。转录因子T-bet在抗炎作用、免疫调节等方面参与COPD发病的炎性反应及肺功能改变,有望成为防治COPD发病的新靶点,为COPD的靶向研究提供新思路。

关键词: T-bet, Th1细胞, Th2细胞, Th17细胞, 慢性阻塞性肺疾病

Abstract: Chronic obstructive pulmonary disease (COPD) is a chronic and progressive respiratory disease. Transcription factor T-bet is involved in the inflammatory response and lung function changes of COPD, which is expected to become a new target for the prevention and treatment of COPD. It might provide a new idea for the targeted research of COPD.

Key words: T-bet, Th1 cell, Th2 cell, Th17 cell, chronic obstructive pulmonary disease

中图分类号:

R563

陈瑜婷, 黄玲, 夏俊杰, 邱宇, 弋可, 王金诚. 转录因子T-bet在慢性阻塞性肺疾病发病中作用的研究进展[J]. 基础医学与临床, 2023, 43(8): 1322-1325.

CHEN Yuting, HUANG Ling, XIA Junjie, QIU Yu, YI Ke, WANG Jincheng. Research progress on the role of transcription factor T-bet in the pathogenesis of chronic obstructive pulmonary disease[J]. Basic & Clinical Medicine, 2023, 43(8): 1322-1325.

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转录因子T-bet在慢性阻塞性肺疾病发病中作用的研究进展

Research progress on the role of transcription factor T-bet in the pathogenesis of chronic obstructive pulmonary disease

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