子宫内膜葡萄糖转运体在胚胎着床中作用的研究进展

doi:10.16352/j.issn.1001-6325.2023.06.1002

基础医学与临床 ›› 2023, Vol. 43 ›› Issue (6): 1003-1007.doi: 10.16352/j.issn.1001-6325.2023.06.1002

子宫内膜葡萄糖转运体在胚胎着床中作用的研究进展

张立雪^1*, 李长兴²

1.西北民族大学医学部,甘肃兰州 730000;
2.青海大学医学院,青海西宁 810001

收稿日期:2021-06-02 修回日期:2022-07-12 出版日期:2023-06-05 发布日期:2023-05-31
通讯作者: ^*1426379458@qq.com
基金资助:
2022年度甘肃省高等学校青年博士基金(2022QB-026);2022年校级本科人才培养质量提高项目(2022XJJG-89);2022年校级创新创业教育改革项目(2022XJCXCYJGXM16)

Research progress on the role of endometrial glucose transporters in embryo implantation

ZHANG Lixue^1*, LI Changxing²

1. Department of Medicine, Northwest Minzu University, Lanzhou 730000;
2. Medical Institute of Qinghai University, Xining 810001, China

Received:2021-06-02 Revised:2022-07-12 Online:2023-06-05 Published:2023-05-31
Contact: ^*1426379458@qq.com

摘要/Abstract

摘要： 葡萄糖转运体是介导葡萄糖跨细胞膜转运的重要载体,分为易化扩散葡萄糖转运体(GLUTs)和钠-葡萄糖协同转运体(SGLTs)以及尚待深入研究的一类葡萄糖转运体SWEETS。胚胎着床过程中子宫内膜上皮细胞葡萄糖的摄取与利用可保障与着床相关功能活动得以正常运行。本文就葡萄糖转运体在胚胎着床中的作用进行阐述,旨在揭示胚胎着床的机制,为着床失败导致的女性不孕及早期流产的诊断治疗提供新的思路。

关键词: 子宫内膜, 葡萄糖转运体, 胚胎着床

Abstract: Glucose transporters are important carriers that mediate glucose transport across cell membranes, including facilitated diffusion glucose transporters (GLUTs), sodium glucose co transporters (SGLTs), and a class of glucose transporters SWEETs that have not been extensively studied. Glucose uptake and utilization of endometrial epithelial cells during implantation can ensure normal implant-related functional activities. The purpose of this paper is to elucidate the role of glucose transporter in embryo implantation in order to further reveal the mechanism of embryo implantation and provide new ideas for the diagnosis and treatment of female infertility and early abortion caused by implantation failure.

Key words: endometrium, glucose transporter, embryo implantation

中图分类号:

R339.22

张立雪, 李长兴. 子宫内膜葡萄糖转运体在胚胎着床中作用的研究进展[J]. 基础医学与临床, 2023, 43(6): 1003-1007.

ZHANG Lixue, LI Changxing. Research progress on the role of endometrial glucose transporters in embryo implantation[J]. Basic & Clinical Medicine, 2023, 43(6): 1003-1007.

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子宫内膜葡萄糖转运体在胚胎着床中作用的研究进展

Research progress on the role of endometrial glucose transporters in embryo implantation

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