Tamm-Horsfall蛋白在急性肾损伤中的作用

doi:10.16352/j.issn.1001-6325.2022.11.1795

基础医学与临床 ›› 2022, Vol. 42 ›› Issue (11): 1795-1798.doi: 10.16352/j.issn.1001-6325.2022.11.1795

Tamm-Horsfall蛋白在急性肾损伤中的作用

许怡文¹, 李清初^1,2*

1.桂林医学院,广西桂林 541199;
2.山东省立第三医院肾内科,山东济南 250031

收稿日期:2021-06-28 修回日期:2021-11-12 出版日期:2022-11-05 发布日期:2022-11-01
通讯作者: ^* liqingchu2013@126.com

Role of Tamm-Horsfall protein in acute kidney injury

XU Yi-wen¹, LI Qing-chu^1,2*

1. Guilin Medical University, Guilin 541199;
2. Department of Nephrology, Shandong Provincial Third Hospital, Jinan 250031,China

Received:2021-06-28 Revised:2021-11-12 Online:2022-11-05 Published:2022-11-01
Contact: ^* liqingchu2013@126.com

摘要/Abstract

摘要： Tamm-Horsfall蛋白(THP),也被称为尿调节素(UMOD),是一种双向释放在血液和尿液中的肾源性蛋白。血和尿中的THP有希望成为早期预测诊断急性肾损伤(AKI)的标志物,还可能作为判断严重程度的指标之一。同时THP可通过抑制活性氧积聚、抗炎性反应和调节巨噬细胞等机制发挥保护AKI中肾功能的作用,有望成为治疗AKI的新靶点。

关键词: Tamm-Horsfall蛋白, 尿调节素, 急性肾损伤

Abstract: The Tamm-Horsfall protein (THP), also known as uromodulin (UMOD), is a kidney-derived protein released bidirectionally in the blood and urine. Blood and urinary THP may be markers of early predictive diagnosis of acute kidney injury(AKI) and possibly as one of the indicators of AKI severity. At the same time, THP plays a role in protecting kidney function in AKI through inhibiting reactive oxygen species accumulation, anti-inflammatory response and regulating macrophages. So it is a potential target in the clinical treatment of AKI.

Key words: Tamm-Horsfall protein, uromodulin, acute kidney injury

中图分类号:

R692

许怡文, 李清初. Tamm-Horsfall蛋白在急性肾损伤中的作用[J]. 基础医学与临床, 2022, 42(11): 1795-1798.

XU Yi-wen, LI Qing-chu. Role of Tamm-Horsfall protein in acute kidney injury[J]. Basic & Clinical Medicine, 2022, 42(11): 1795-1798.

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Tamm-Horsfall蛋白在急性肾损伤中的作用

Role of Tamm-Horsfall protein in acute kidney injury

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