梗阻性膀胱逼尿肌功能失调分子机制的研究进展

doi:10.16352/j.issn.1001-6325.2022.10.1606

基础医学与临床 ›› 2022, Vol. 42 ›› Issue (10): 1606-1610.doi: 10.16352/j.issn.1001-6325.2022.10.1606

梗阻性膀胱逼尿肌功能失调分子机制的研究进展

刘胜来^1,2, 田大伟^1,2, 吴长利^1,2*

1.天津医科大学第二医院泌尿外科/天津市泌尿外科研究所/天津市泌尿外科基础医学重点实验室, 天津 300211;
2.天津医科大学中新生态城医院泌尿肾病科, 天津 300467

收稿日期:2021-06-23 修回日期:2021-11-11 出版日期:2022-10-05 发布日期:2022-09-23
通讯作者: * wucl2003@163.com
基金资助:
天津市滨海新区卫健委科技项目(2017BWKY034); 天津市“131”创新型人才培养工程专项(滨人才[2020]7号)

Advances in molecular mechanism of bladder detrusor dysfunction

LIU Sheng-lai^1,2, TIAN Da-wei^1,2, WU Chang-li^1,2*

1. Department of Urology, the Second Hospital of Tianjin Medical University/Tianjin Key Laboratory of Basic Urology/Tianjin Urology Institute, Tianjin 300211;
2. Department of Urology, Sino-Singapore Eco-City Hospital of Tianjin Medical University, Tianjin 300467, China

Received:2021-06-23 Revised:2021-11-11 Online:2022-10-05 Published:2022-09-23
Contact: * wucl2003@163.com

摘要/Abstract

摘要： 膀胱出口梗阻 (BOO) 增加了排尿阻力,也延长了膀胱内高压的持续时间。腔内压力升高使逼尿肌受到的静水压力和机械拉伸力超出负荷时,促发了肌细胞以机械张力应激、低氧、缺血再灌注损伤 (IRI)为始的级联反应,引起细胞内代谢的改变和细胞外基质的重构。此病理损伤具有不可逆性,最终的结局是膀胱功能失代偿,出现肾衰竭等严重并发症。确切病理机制尚不完全清楚,发病机制的探索有利于疾病的早期发现,实现精准治疗。

关键词: 膀胱出口梗阻, 膀胱重构, 尿路上皮纤维化, 平滑肌细胞

Abstract: Bladder outlet obstruction (BOO) increases micturition resistance and prolongs the duration of intravesical hypertension. The intravesical pressure overloads the hydrostatic pressure and mechanical tensile force of detrusor,which triggers the cascade reaction of muscle cells starting from mechanical tension stress, hypoxia and ischemia-reperfusion injury (IRI), leading to changes in intracellular metabolism and reconstruction of extracellular matrix.The change of interstitial components is irreversible injury, and there is no effective treatment measures in the decompensation stage. At present, the exact pathogenesis is not completely clear. The study on the pathogenesis of BOO may support early detection of obstructive dysuria, which is of great significance for clinical treatment.

Key words: bladder outlet obstruction, bladder remodeling, urothelial fibrosis, smooth muscle

中图分类号:

R697

刘胜来, 田大伟, 吴长利. 梗阻性膀胱逼尿肌功能失调分子机制的研究进展[J]. 基础医学与临床, 2022, 42(10): 1606-1610.

LIU Sheng-lai, TIAN Da-wei, WU Chang-li. Advances in molecular mechanism of bladder detrusor dysfunction[J]. Basic & Clinical Medicine, 2022, 42(10): 1606-1610.

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梗阻性膀胱逼尿肌功能失调分子机制的研究进展

Advances in molecular mechanism of bladder detrusor dysfunction

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