FTO介导RNA的m6A修饰与发育的研究进展

doi:10.16352/j.issn.1001-6325.2022.10.1591

基础医学与临床 ›› 2022, Vol. 42 ›› Issue (10): 1591-1595.doi: 10.16352/j.issn.1001-6325.2022.10.1591

FTO介导RNA的m6A修饰与发育的研究进展

潘明敏, 王启阳, 杨丽萍^*

河南中医药大学中西医结合基础学科, 河南郑州 450046

收稿日期:2021-04-25 修回日期:2021-10-15 出版日期:2022-10-05 发布日期:2022-09-23
通讯作者: * bioylp@126.com
基金资助:
国家自然科学基金(81973596)

Progress in research on m6A modification of FTO mediated-RNA and development

PAN Ming-min, WANG Qi-yang, YANG Li-ping^*

Department of Integrated Chinese and Western Medicine, Henan University of Chinese Medicine, Zhengzhou 450046,China

Received:2021-04-25 Revised:2021-10-15 Online:2022-10-05 Published:2022-09-23
Contact: * bioylp@126.com

摘要/Abstract

摘要： 人类脂肪和肥胖相关蛋白FTO作为第一个被确证的N⁶-甲基腺苷(m6A)去甲基化酶,证明了RNA修饰存在可逆性,同时也揭开了m6A修饰的研究序幕。越来越多的学者试着从m6A修饰角度探讨基因表达调控的具体机制。m6A修饰功能需要甲基化酶、去甲基化酶、结合蛋白的共同参与完成。FTO可催化mRNA上m6A修饰的去甲基化,且在人体组织中广泛表达并参与调控多种生物学过程。本文综述去甲基化酶FTO及其介导的m6A/RNA修饰与体脂发育、胚胎发育、大脑发育、神经发育的关系,以期能够深入了解FTO的功能以及作用机制。

关键词: FTO, mRNA, m6A, 发育

Abstract: Human fat mass and obesity associated protein FTO is the first confirmed N⁶-methyladenosine(m6A) demethylase, which demonstrated the existence of reversible RNA modification, and also unveiled the prelude of m6A modification research. More and more researchers have tried to explore the specific mechanism of gene expression regulation at the level of m6A modification. It is found that m6A modification function requires the joint participation of methylesterase, demethylase, and binding protein to complete. FTO catalyze the demethylation of m6A modifications on mRNAs and is widely expressed in human tissues and participate in the regulation of various biological processes. This paper outlines the relationship between demethylase FTO and its mediated m6A/RNA modification and the development of body fat tissue, embryonic tissue, brain and neuro-system, hoping to gain insight into the function and mechanism of FTO.

Key words: FTO, mRNA, m6A, development

中图分类号:

R363

潘明敏, 王启阳, 杨丽萍. FTO介导RNA的m6A修饰与发育的研究进展[J]. 基础医学与临床, 2022, 42(10): 1591-1595.

PAN Ming-min, WANG Qi-yang, YANG Li-ping. Progress in research on m6A modification of FTO mediated-RNA and development[J]. Basic & Clinical Medicine, 2022, 42(10): 1591-1595.

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FTO介导RNA的m6A修饰与发育的研究进展

Progress in research on m6A modification of FTO mediated-RNA and development

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