心肌细胞钙稳态失调在心力衰竭中作用的研究进展

doi:10.16352/j.issn.1001-6325.2022.03.008

基础医学与临床 ›› 2022, Vol. 42 ›› Issue (3): 502-506.doi: 10.16352/j.issn.1001-6325.2022.03.008

心肌细胞钙稳态失调在心力衰竭中作用的研究进展

刘峰宇, 韩薇^*

哈尔滨医科大学附属第一医院心血管内科, 黑龙江哈尔滨 150000

收稿日期:2020-10-09 修回日期:2021-01-09 出版日期:2022-03-05 发布日期:2022-03-04
通讯作者: ^* dr.hanwei@foxmail.com
基金资助:
黑龙江省自然科学基金(ZD2020H002); 上海市浦东新区卫生系统重点学科项目(PWZxk2017-01)

Research progress on the role of myocardial cell calcium homeostasis dysregulation in heart failure

LIU Feng-yu, HAN Wei^*

Department of Cardiology,the First Affliated Hospital of Harbin Medical University,Harbin 150000,China

Received:2020-10-09 Revised:2021-01-09 Online:2022-03-05 Published:2022-03-04
Contact: ^* dr.hanwei@foxmail.com

摘要/Abstract

摘要： 心肌细胞的钙稳态依赖于质膜、肌/内质网(SR)、线粒体等对钙(Ca²⁺)转运的调节。胞质钙超载、SR钙渗漏等在内的钙稳态失调,使心肌细胞钙瞬变减低,收缩力下降是心力衰竭的主要特征之一。

关键词: 钙稳态, 心力衰竭, 钙ATP酶2a, 2型兰尼碱受体(RyR2)

Abstract: Calcium homeostasis of cardiomyocytes depends on the regulation of calcium(Ca²⁺) transportation through plasma membrane, sarco/endoplasmic reticulum(SR) and mitochondria. One of the main characteristics of heart failure is calcium homeostasis, including cytosolic calcium overload and SR calcium leakage, which leads to transient decrease of myocardial calcium and decrease of contractility.

Key words: calcium homeostasis, heart failure, calcium ATPase 2a, ryanodine receptor 2(RyR2)

中图分类号:

R541

刘峰宇, 韩薇. 心肌细胞钙稳态失调在心力衰竭中作用的研究进展[J]. 基础医学与临床, 2022, 42(3): 502-506.

LIU Feng-yu, HAN Wei. Research progress on the role of myocardial cell calcium homeostasis dysregulation in heart failure[J]. Basic & Clinical Medicine, 2022, 42(3): 502-506.

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心肌细胞钙稳态失调在心力衰竭中作用的研究进展

Research progress on the role of myocardial cell calcium homeostasis dysregulation in heart failure

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