核壳结构树状大分子的设计及其生物医学应用

doi:10.16352/j.issn.1001-6325.2022.01.010

摘要/Abstract

摘要： 核壳结构树状大分子(core-shell tecto dendrimers,CSTDs)是一类以相对高代树状大分子为核、相对低代树状大分子为壳的超结构树状大分子纳米体系。越来越多的研究表明,利用不同代的聚酰胺-胺[poly(amidoamine),PAMAM]树状大分子作为反应模块构建的CSTDs不仅具有比相对高代树状大分子更优异的理化性能,还克服了单代树状大分子在医学应用上的一些局限性(如有限的载药量和EPR效应等)。在此,本文综述了近年来CSTDs的几种制备方法,并分类介绍了基于CSTDs的纳米平台在生物学成像、化疗、基因治疗以及联合治疗等方面的应用。最后,结合CSTDs研究现状分析了其当前在生物医学领域中的挑战和机遇。

关键词: 核壳结构树状大分子, 聚酰胺-胺树状大分子, 合成, 成像, 治疗

Abstract: Core-shell tecto dendrimers (CSTDs) are a kind of superstructured dendrimeric nanoconstructs with relatively high-generation dendrimers as the cores and low-generation dendrimers as the shells. Recently, there is growing evidence that the performance of CSTDs constructed with poly(amidoamine) (PAMAM) dendrimers of different generations as reactive modules is not only superior to that of single-generation dendrimers, but also overcomes some biomedical limitations (e.g., restricted drug loading capacity, limited tumor passive targeting based on enhanced permeability and retention effect) of single-generation dendrimers. Herein, the design of CSTDs for biological imaging, chemotherapy, gene therapy, and combination therapy are reviewed. The current challenges and future development prospects of CSTDs in the field of biomedicine are also analyzed.

Key words: core-shell tecto dendrimers, poly(amidoamine) dendrimers, synthesis, imaging, therapy

中图分类号:

Q819

宋聪, 汪大圆, 沈明武, 史向阳. 核壳结构树状大分子的设计及其生物医学应用[J]. 基础医学与临床, 2022, 42(1): 15-25.

SONG Cong, WANG Da-yuan, SHEN Ming-wu, SHI Xiang-yang. Design and biomedical applications of core-shell tecto dendrimers[J]. Basic & Clinical Medicine, 2022, 42(1): 15-25.

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