细胞内凝血因子ⅩⅢ研究进展

摘要/Abstract

摘要： 凝血因子ⅩⅢ(FⅩⅢ)是血浆转谷氨酰胺酶家族的一员。在血浆中FⅩⅢ(pFⅩⅢ)由2个催化性A亚基及2个非催化性B亚基以非共价键结合形成异源四聚体(FⅩⅢ-A2B2)。在细胞内,FⅩⅢ以A亚单位同源二聚体(FⅩⅢ-A2)形式存在。虽然目前认为细胞内FⅩⅢ(cFⅩⅢ)可以通过一种未知的机制从细胞内外化,并交联细胞外底物从而参与多种的病理生理过程,其具体的功能和机制还需要系统的研究来阐明。

关键词: 细胞内凝血因子ⅩⅢ, 血液凝固, 吞噬作用, 炎性反应

Abstract: Coagulation factor ⅩⅢ (FⅩⅢ) is a member of the plasma transglutaminase family.Plasma FⅩⅢ (pFⅩⅢ)consists of two catalytic A subunits and two non-catalytic B subunits(FⅩⅢ-A2B2)combined with non-covalent bonds to form a heterotetramer.The cellular FⅩⅢ(cFⅩⅢ) exists in a form of A subunit homodimer(FⅩⅢ-A2).Although it is currently believed that cellular FⅩⅢ can be internalized and externalized from the cell through an unknown mechanism and cross-linked extracellular substrates to function in a variety of pathophysiological events,its specific functions and mechanisms need to be clarified by further systematic research.

Key words: cellular coagulation factor ⅩⅢ, haemostasis, phagocytosis, inflammation

中图分类号:

R363.1

薛雨佳, 李子坚. 细胞内凝血因子ⅩⅢ研究进展[J]. 基础医学与临床, 2021, 41(11): 1680-1683.

XUE Yu-jia, LI Zi-jian. Research progress of cellular coagulation factor ⅩⅢ[J]. Basic & Clinical Medicine, 2021, 41(11): 1680-1683.

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