酸性核质DNA结合蛋白1的研究进展

基础医学与临床 ›› 2021, Vol. 41 ›› Issue (5): 753-757.

酸性核质DNA结合蛋白1的研究进展

崔亚婷¹, 勾文峰², 魏会强², 于江², 侯文彬^2*, 李祎亮^2*

1.天津中医药大学,天津 301617;
2.中国医学科学院北京协和医学院放射医学研究所天津市放射医学与分子核医学重点实验室,天津 300192

收稿日期:2021-03-08 修回日期:2021-03-20 出版日期:2021-05-05 发布日期:2021-05-06
通讯作者: ^*liyiliang@irm-cams.ac.cn; houwenbin@irm-cams.ac.cn
基金资助:
中国医学科学院医学与健康科技创新工程 (2016-I2M-3-022);中央高校基本科研业务费专项(3332020057);天津市科技计划(18ZXXYSY00110); 天津市自然科学基金(18JCQNJC09500)

Research progress of acidic nucleoplasmic DNA-binding protein 1

CUI Ya-ting¹, GOU Wen-feng², WEI Hui-qiang², YU Jiang², HOU Wen-bin^2*, LI Yi-liang^2*

1. Tianjin University of Traditional Chinese Medicine,Tianjin 301617;
2. Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, CAMS & PUMC, Tianjin 300192, China

Received:2021-03-08 Revised:2021-03-20 Online:2021-05-05 Published:2021-05-06
Contact: ^*liyiliang@irm-cams.ac.cn; houwenbin@irm-cams.ac.cn

摘要/Abstract

摘要： 酸性核质DNA结合蛋白1(And-1/WDHD1)是一种天然嵌合蛋白,其包含WD40重复序列(WD-repeat)和高迁移率组蛋白框结构域(HMG-box motif)两大蛋白家族特性。And-1在多种肿瘤细胞中过表达,在整个细胞周期过程中参与了预复制复合体(Pre-RC)的组装、DNA复制、检查点激活、DNA修复以及姐妹染色单体内聚等多种功能调控。And-1可作为细胞周期调控的新型靶点,用于广谱抗癌新药的开发。本文重点针对近年来And-1的结构特征、生化功能及在癌中的潜在作用等研究进行综述,以期望为And-1进一步的研究和新药开发提供参考。

关键词: 酸性核质DNA结合蛋白(And-1), WD40重复序列(WD-repeat), 高迁移率组(HMG), 新型靶点

Abstract: Acidic nucleoplasmic DNA-binding protein 1 (And-1/WDHD1) as a natural chimerical protein, is characterized by containing the WD-repeat and the HMG-box motif families. And-1 is over-expressed in multiple tumors and involved in the whole cell cycle containing prereplication complex (Pre-RC) assembly, DNA replication, checkpoint activation, DNA repair and sister chromatid cohesion establishment. As a novel target for cell cycle regulation, And-1 can be used in the development of broad-spectrum anti-cancer drugs. This article focuses on the research on the structural characteristics, biochemical functions and potential roles of And-1 in cancer in recent years, in order to provide references for the further research of And-1 and the development of new drugs.

Key words: acidic nucleoplasmic DNA-binding protein 1(And-1), WD40(WD-repeat), high mobility group(HMG), novel target

中图分类号:

崔亚婷, 勾文峰, 魏会强, 于江, 侯文彬, 李祎亮. 酸性核质DNA结合蛋白1的研究进展[J]. 基础医学与临床, 2021, 41(5): 753-757.

CUI Ya-ting, GOU Wen-feng, WEI Hui-qiang, YU Jiang, HOU Wen-bin, LI Yi-liang. Research progress of acidic nucleoplasmic DNA-binding protein 1[J]. Basic & Clinical Medicine, 2021, 41(5): 753-757.

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