GA/HbA1c比值与2型糖尿病合并非酒精性脂肪肝相关

基础医学与临床 ›› 2020, Vol. 40 ›› Issue (12): 1636-1639.

GA/HbA1c比值与2型糖尿病合并非酒精性脂肪肝相关

卢亚男¹, 刘丽俊¹, 李伟^2*

1.承德医学院附属医院内分泌科, 河北承德 067000;
2.中国医学科学院北京协和医学院北京协和医院内分泌科, 北京 100073

收稿日期:2020-05-16 修回日期:2020-08-26 出版日期:2020-12-05 发布日期:2020-11-30
通讯作者: ^* weili0012@aliyun.com
基金资助:
河北省科技厅项目(15277755D)

Correlation between GA/HbA1c ratio and NAFLD complications in patients with type 2 diabetes mellitus

LU Ya-nan¹, LIU Li-jun¹, LI Wei^2*

1. Department of Endocrinology, the Affiliated Hospital of Chengde Medical College, Chengde 067000;
2. Department of Endocrinology, Peking Union Medical College Hospital, CAMS & PUMC,Beijing 100730, China

Received:2020-05-16 Revised:2020-08-26 Online:2020-12-05 Published:2020-11-30
Contact: ^* weili0012@aliyun.com

摘要/Abstract

摘要： 目的探讨2型糖尿病(T2DM)合并非酒精性脂肪肝(NAFLD)患者糖化白蛋白(GA)、糖化血红蛋白(HbA1c)、GA/HbA1c比值水平与NAFLD之间的关系。方法选自2017年2至12月住院的2型糖尿病患者,共502例,依据有无NAFLD分为单纯2型糖尿病组281例和2型糖尿病合并NAFLD组221例。两组间相关生化指标、GA、HbA1c以及GA/HbA1c比较采用t检验及秩和检验,并进行GA/HbA1c与指标间相关性分析,以及2型糖尿病合并NAFLD 影响因素回归分析。结果在T2DM合并NAFLD组GA/HbA1c高于单纯T2DM组(P＜0.05),GA/HbA1c与GA、CRP、FPG呈正相关(P＜0.05),与空腹C肽呈负相关(P＜0.05)。Logistic回归分析发现GA、GA/HbA1c是T2DM合并 NAFLD发生危险因素(P＜0.05)。ROC曲线:GA/HbA1c曲线下面积为0.745,GA曲线下面积为0.660。结论 GA/HbA1c是T2DM合并 NAFLD的独立危险因素。

关键词: 2型糖尿病, 非酒精性脂肪肝, 糖化白蛋白, 糖化血红蛋白

Abstract: Objective To study the relationship between glycated albumin (GA), glycated hemoglobin (HbA1c), GA/HbA1c ratio and NAFLD in patients with type 2 diabetes and non-alcoholic fatty liver. Methods A total of 502 patients with type 2 diabetes hospitalized from February to December 2017 were divided into 281 cases of type 2 diabetes and 221 cases of type 2 diabetes complicated with NAFLD based on the presence or absence of NAFLD. The correlation biochemical indexes, GA, HbA1c and GA/HbA1c were compared between the two groups using t test and rank sum test, and the correlation analysis of GA/HbA1c ratio and regression analysis of influencing factors of type 2 diabetes combined with NAFLD were performed. Results GA/HbA1c in T2DM complicated with NAFLD group was higher than that in T2DM group(P＜0.05). GA/HbA1c was positively correlated with GA, CRP and FPG(P＜0.05), and negatively correlated with fasting C-peptide(P＜0.05). Logistic regression analysis showed that GA and GA/HbA1c were risk factors for T2DM complicated with NAFLD(P＜0.05). ROC curve: area under the curve of GA/HbA1c was 0.745, area under the curve of GA was 0.660. Conclusions GA/HbA1c is an independent risk factor for T2DM complicated with NAFLD.

Key words: type 2 diabetes mellitus, nonalcoholic fatty liver, glycated albumin, glycated hemoglobin

中图分类号:

R587.1

卢亚男, 刘丽俊, 李伟. GA/HbA1c比值与2型糖尿病合并非酒精性脂肪肝相关[J]. 基础医学与临床, 2020, 40(12): 1636-1639.

LU Ya-nan, LIU Li-jun, LI Wei. Correlation between GA/HbA1c ratio and NAFLD complications in patients with type 2 diabetes mellitus[J]. Basic & Clinical Medicine, 2020, 40(12): 1636-1639.

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