钙敏感受体在动脉粥样硬化中的作用研究进展

基础医学与临床 ›› 2020, Vol. 40 ›› Issue (3): 395-398.

钙敏感受体在动脉粥样硬化中的作用研究进展

商瑀家, 李玉霞, 宋佳新, 李宏霞^*

哈尔滨医科大学基础医学院病理生理学教研室, 黑龙江哈尔滨 150086

收稿日期:2019-04-30 修回日期:2019-09-27 出版日期:2020-03-05 发布日期:2020-03-02
通讯作者: ^*lihongxia_396@163.com
基金资助:
国家自然科学基金(81300200)

Research progress on the role of calcium sensing receptor in atherosclerosis

SHANG Yu-jia, LI Yu-xia, SONG Jia-xin, LI Hong-xia^*

Department of Pathophysiology,School of Basic Medicine,Harbin Medical University,Harbin 150086,China

Received:2019-04-30 Revised:2019-09-27 Online:2020-03-05 Published:2020-03-02
Contact: ^*lihongxia_396@163.com

摘要/Abstract

摘要： 钙敏感受体(CaSR)是G蛋白偶联受体C家族的成员之一,广泛表达于体内不同组织细胞,参与机体多种病理生理过程。CaSR能够通过调控血管内皮细胞损伤、炎性反应、血管平滑肌细胞增殖和迁移及血管钙化过程,参与动脉粥样硬化的发生发展。

关键词: 钙敏感受体, 动脉粥样硬化, 血管平滑肌细胞

Abstract: Calcium sensing receptor (CaSR) is a member of the G protein-coupled receptor C family.It is widely expressed in different tissue cells in the body and functions in various pathophysiological processes of the body. CaSR can participate in the development of atherosclerosis by regulating vascular endothelial cell injury,inflammatory response,proliferation and migration of vascular smooth muscle cells and vascular calcification.

Key words: calcium sensing receptor, atherosclerosis, vascular smooth muscle cells

中图分类号:

R543.5

商瑀家, 李玉霞, 宋佳新, 李宏霞. 钙敏感受体在动脉粥样硬化中的作用研究进展[J]. 基础医学与临床, 2020, 40(3): 395-398.

SHANG Yu-jia, LI Yu-xia, SONG Jia-xin, LI Hong-xia. Research progress on the role of calcium sensing receptor in atherosclerosis[J]. Basic & Clinical Medicine, 2020, 40(3): 395-398.

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