基础医学与临床 ›› 2019, Vol. 39 ›› Issue (10): 1499-1502.

• 短篇综述 • 上一篇    下一篇

牙髓干细胞成牙及成骨向分化调控方法的研究进展

孟士翔,郭晓霞   

  1. 首都医科大学
  • 收稿日期:2018-09-25 修回日期:2019-04-03 出版日期:2019-10-05 发布日期:2019-09-25
  • 通讯作者: 郭晓霞 E-mail:gxxj@sohu.com

Research advance on osteo/odontogenic differentiation regulation methods of dental pulp stem cells

Shi-Xiang MENG1,   

  • Received:2018-09-25 Revised:2019-04-03 Online:2019-10-05 Published:2019-09-25

摘要: 牙髓干细胞(DPSC)是一种位于牙髓腔内,具有较强的自我更新能力和多向分化潜能的间充质干细胞,在再生医学中有着十分良好的应用前景。本文介绍了化合物诱导分化、物理方法诱导分化和支架及表面形貌诱导分化等调控方法与途径,并分析提出了不同调控方法的优势与不足,为牙髓干细胞成牙本质及成骨向分化调控的相关研究提供参考。

关键词: 牙髓干细胞, 牙本质, 再生, 分化, 调控

Abstract: Dental pulp stem cells (DPSC) are mesenchymal stem cells that present in dental pulp cavity, with high self-renewal ability and multi-lineage differentiation potential, showing good prospects to use in regenerative medicine. However, current research on mechanisms and measures of inducing differentiation of dental pulp stem cells is insufficient. Advance of research on osteo/odontogenic differentiation regulation methods of dental pulp stem cells in recent years is reviewed and compared in this article.

Key words: Dental pulp stem cell, dentin, regeneration, differentiation, regulation