关键词: 胃肿瘤, HMGA2, HDAC6

Abstract: Objective To investigate the expressions and correlationship of HMGA2 and HDAC6 in the gastric carcinoma(GC) tissues,corresponding peritumor tissues and normal tissues. Methods Immunocytochemistry staining,Real-time PCR(RT-PCR) and Western blotting were used to detect the protein and mRNA expressions of HMGA2 and HDAC6 in GC tissues,paired peritumor tissues and normal tissues,the correlation was analyzed between the expression and the clinicopathological characteristics of GC. Results The positive expression of HMGA2 and HDAC6 were respectively 69.51％（57/82） and 65.58％ (54/82) in GC, while peritumor tissues and normal gastric tissues were 14.63％（12/82）,12.19％（10/82） and 9.76％(8/82),7.32％(6/82), (P＜0.05) ;The mRNA and protein levels of HMGA2 and HDAC6 in GC tissues were higher than those in the paired peritumor tissues and normal tissues(P＜0.05). Furthermore,the expression was obviously correlated to clinical stage of GC and lymph node metastases (P＜0.05). A positive correlation was found between the expression of HMGA2 and HDAC6 in GC tissues(r=0.56，P＜0.05). Conclusions The high expression of HMGA2 and HDAC6 coexist in GC tissues, It may be related to malignant transformation of tumor.

Key words: gastric carcinoma, high mobility group protein A2(HMGA2), histone deacetylase 6(HDAC6)