关键词: 恶性肿瘤, 外泌体, 蛋白质组学, 进展

Abstract: Exosomes are vesicles of endocytic origin released from different cell types under both normal and pathological conditions. Proteomics is an emerging discipline for studying composition and mechanics and interaction of proteins with regard to disease occurrence、cellular metabolism ,etc. Progress of Sdudying exosomes from tumor cell or associated with tumor on proteomics technology platforms in aspect of clarifying mechanisms of shaping and sustaining microenviroment of tumor growth and survival and metastasis, induce tumor proliferation, Immunosuppressive effects or immune evasion,and discovering biomarker,makes a promising prospect of exsomes in clinical diagnosis and treatment.

Key words: malignant tumor, exosomes, proteomics, progress