关键词: 白色念珠菌, 基本结构, 基因分型, 致病, 耐药, 应激

Abstract: With the increased application of broad-spectrum antibiotics, immunosuppression, and cytotoxic therapies, Candida albicans, being an conditioned pathogen, has become one of the common nosocomial infection pathogens. Recent studies showed that the pathogenicity of Candida albicans depends upon hypothetical virulence factors including the adhesion to host cells, transition from yeast to mycelium, and production of secreted hydrolytic enzymes. The impacts on the evolution of drug resistance and adaptation to environmental stress rely on multiple machanisms and remains largely unexplored. Therefore, to understand the basic structure, genotype, pathogenesis, drug resistance of Candida albicans and the influence of environmental stress on Candida albicans has great clinical significance in disease diagnosis, treatment and prevention.

Key words: Candida albicans, basic structure, genotype, pathopoiesia, resistance, stress