癌症组织中miR-100的表达变化和靶点研究进展

基础医学与临床 ›› 2014, Vol. 34 ›› Issue (1): 138-141.

癌症组织中miR-100的表达变化和靶点研究进展

周韶梅,盛望,曾毅,李泽琳

北京工业大学

收稿日期:2013-07-11 修回日期:2013-11-20 出版日期:2014-01-05 发布日期:2013-12-26
通讯作者: 周韶梅 E-mail:zhoushaomei@emails.bjut.edu.cn

The proceeding research of the expression changes and targets of miR-100 in cancer tissue

Received:2013-07-11 Revised:2013-11-20 Online:2014-01-05 Published:2013-12-26
Contact: 周韶梅 E-mail:zhoushaomei@emails.bjut.edu.cn

摘要/Abstract

摘要： miR-100序列高度保守，在实体瘤的多数报道中，miR-100表达降低，调高miR-100的表达对肿瘤细胞起到抑制作用。但有报道miR-100表达升高与肿瘤的复发有关。miR-100表达量的多少与病理分期和病情进展的关系，也存在着分歧。目前已证实的miR-100的靶点有数种，对肿瘤细胞分别起到抑制增值、导致细胞周期停滞、促进调亡，增加癌细胞对放化疗的敏感性等作用。

关键词: 癌症，miR-100，靶点

Abstract: The sequence of miR-100 is highly conserved. In most of the literature about solid tumor, decreased expression of miR-100 were reported, and increase the expression show inhibitory effects on tumor cells. But also, there are reports that over expresstion correlated with tumor recurrence. Still, there are different views on the relationship between the expressions of miR-100 with the pathological staging and disease progression. Several targets have been confirmed, that control the cell proliferation, cell cycle and apoptosis, and regulate the sensitivity of cancer cells to chemotherapy and radiotherapy.

Key words: cancer, miR-100, target

周韶梅盛望曾毅李泽琳. 癌症组织中miR-100的表达变化和靶点研究进展[J]. 基础医学与临床, 2014, 34(1): 138-141.