基础医学与临床 ›› 2013, Vol. 33 ›› Issue (11): 1493-1495.

• 临床园地 • 上一篇    下一篇

术中亚甲蓝标定清扫淋巴结提高贲门癌患者生存率

颜云鹏,毛须平,陈建红,张志宇,马人杰,潘忠军   

  1. 南通大学附属丹阳医院
  • 收稿日期:2013-07-11 修回日期:2013-09-16 出版日期:2013-11-05 发布日期:2013-10-28
  • 通讯作者: 颜云鹏 E-mail:yanyp828@163.com
  • 基金资助:
    江苏省镇江市科技计划项目

Intraoperative lymph node dissection of methylene blue calibration improves cardiac cancer survival rate

  • Received:2013-07-11 Revised:2013-09-16 Online:2013-11-05 Published:2013-10-28

摘要: 目的 分析术中直视下亚甲蓝标定贲门周围淋巴结,引导清扫根治,观察对术后3年无病生存率、5年总生存率的影响。方法 选择年龄小于70岁,贲门癌单瘤体直径小于8cm,Ⅰ期至ⅢB期患者,随机分为2组。A组常规行D2根治术。B组术中在瘤体周围注入亚甲蓝,显示周围淋巴结,引导清扫切除,术后随访5年。结果 A组术后3年无病生存率和5年总生存率分别为59%和37%,B组为74%和53%。结论 术中直视下行瘤体周围淋巴结标定能较完整地切除前哨淋巴结及被染色而肉眼不易发现的<2mm阳性微小淋巴结,提高了术后3年无病生存率和5年总生存率。该技术简单可行、实用性强,临床可以推广应用。

关键词: 贲门癌, 淋巴转移, 淋巴结染色, 生存率

Abstract: Objectives To analysis the effect of open surgery of methylene blue calibration around the lower esophageal segment cardia lymph on postoperative 3-year disease-free survival rate and 5-year overall survival rate. Methods Patients less than 70-year-old, the cardia single tumor less than 8cm, stage Ⅰ to ⅢB were randomly divided into 2 groups. Group A: D2 radical mastectomy. Group B: injected into the methylene blue around the cardia tumor and surrounding lymph nodes, so as to guide cleaning resection. Patients were followed up for 5 years.Results A postoperative 3-year disease-free survival and overall 5-year survival rates were 59% and 37%. Group B 74% and 53% respectively.Conclusions Intraoperative lymph nodes around the tumor look straight down the calibration can be more complete excision and sentinel lymph node was stained and visually difficult to find< 2mm tiny positive lymph nodes, increased after 3-year disease-free survival and overall 5-year survival rate. The technique is simple and feasible, practical, clinical applications could be extended.

Key words: the cardia tumor, lymphatic metastasis, lymph node staining, survival rate

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