关键词: 纤维连接蛋白, Ⅲ度烧伤, 小鼠

Abstract: Objective To study the effects and differences of different purities of FN on wound healing of Ⅲ-degree burns in mice under the same concentration. Methods Establishing a model of skin Ⅲ-degree burns in mice, and dividing randomly into five groups: FN high purity group (85%), middle purity group (75%), low purity group (65%), Bei Fuji positive control group and blank control group. Observing the wound healing time,decrustation time and pathological changes in each group. Results All the different purities groups of FN could shorten the wound healing time and decrustation time,and significantly improved pathological morphology of the burn skin,compared with the blank control group. Conclusions FN can significantly improve the healing time of skin Ⅲ-degree burns in mice. The middle purity group might have the clinical value.

Key words: FN, Skin Ⅲ-degree burns, mice