细胞移植联合其他治疗策略在治疗白癜风中的研究进展

doi:10.16352/j.issn.1001-6325.2024.11.1584

基础医学与临床 ›› 2024, Vol. 44 ›› Issue (11): 1584-1588.doi: 10.16352/j.issn.1001-6325.2024.11.1584

细胞移植联合其他治疗策略在治疗白癜风中的研究进展

刘尚昆¹, 王红娟², 康晓静^2*

1.新疆医科大学研究生院,新疆乌鲁木齐 830001;
2.新疆维吾尔自治区人民医院皮肤性病科新疆皮肤病临床医学研究中心新疆皮肤病研究重点实验室(XJYS1707),新疆乌鲁木齐 830001

收稿日期:2023-11-13 修回日期:2024-04-02 出版日期:2024-11-05 发布日期:2024-10-31
通讯作者: ^*drkangxj666@163.com
基金资助:
国家自然科学基金(82173406)

Advances in cell transplantation combined with other therapeutic strategies in the treatment for vitiligo

LIU Shangkun¹, WANG Hongjuan², KANG Xiaojing^2*

1. Graduate School of Xinjiang Medical University, Urumqi 830001;
2. Department of Dermatology and Venereology, People's Hospital of Xinjiang Uygur Autonomous Region, Xinjiang Clinical Medical Research Center for Dermatologic Diseases, Xinjiang Key Laboratory of Dermatology Research (XJYS1707), Urumqi 830001,China

Received:2023-11-13 Revised:2024-04-02 Online:2024-11-05 Published:2024-10-31
Contact: ^*drkangxj666@163.com

摘要/Abstract

摘要： 白癜风是一种以黑素细胞数量减少或功能丧失为特征的获得性色素脱失性皮肤病。目前白癜风常规治疗手段有药物治疗、光疗及外科治疗。细胞移植作为治疗白癜风的一种重要外科手段,对于稳定期、局限型或其他方法治疗无效的白癜风疗效确切,但复色率差异较大。如何最大程度实现难治性白癜风患者皮损复色,联合治疗是较好选择。近年来,关于细胞移植联合策略的相关报道逐渐增多,为提高白癜风患者的皮损复色率带来新的希望。本文对细胞移植联合策略的应用进展进行综述,旨在为难治性白癜风临床治疗提供更多选择。

关键词: 白癜风, 细胞移植, 联合治疗, 黑素细胞

Abstract: Vitiligo is an acquired depigmentation skin disease characterized by a decrease or loss of function of melanocytes.The conventional treatment for vitiligo include drug therapy, phototherapy and surgical treatment. As an important surgical treatment for vitiligo, cell transplantation is effective especially for the case which is stable, limited or fail to respond to other methods,but the recoloration rate varies greatly. The combination therapy is a better choice to maximize the recoloration of skin lesions in patients with refractory vitiligo. In recent years, reports on the combined strategy of cell transplantation have gradually increased, bringing new hope to improve the rate of discoloration of vitiligo patients. This paper reviews the progress of the application of cell transplantation combination strategy aiming for providing more options for the clinical treatment of refractory vitiligo.

Key words: vitiligo, cell transplantation, combination therapies, celanocyte

中图分类号:

R758.41

刘尚昆, 王红娟, 康晓静. 细胞移植联合其他治疗策略在治疗白癜风中的研究进展[J]. 基础医学与临床, 2024, 44(11): 1584-1588.

LIU Shangkun, WANG Hongjuan, KANG Xiaojing. Advances in cell transplantation combined with other therapeutic strategies in the treatment for vitiligo[J]. Basic & Clinical Medicine, 2024, 44(11): 1584-1588.

参考文献

[1] Bergqvist C, Ezzedine K. Vitiligo: a review[J]. Dermatology, 2020, 236: 571-592.
[2] Liu B, Chen HH, Liu ZH, et al. The clinical efficacy of treatment using the autologous non-cultured epidermal cell suspension technique for stable vitiligo in 41 patients[J]. Dermatolog Treat, 2021, 32: 90-94.
[3] Zhu MC, Ma HY, Zhan Z, et al. Detection of auto antibodies and transplantation of cultured autologous melanocytes for the treatment of vitiligo[J]. Exp Ther Med,2017, 13: 23-28.
[4] Zhang D, Wei X, Hong W, et al. A retrospective study of long term follow-up of 2283 vitiligo patients treated by autologous, non-cultured melanocyte-keratinocyte transplantation[J]. Aging (Albany NY), 2021, 13: 5415-5425.
[5] Shi HX, Zhang RZ, Xu B, et al. Experimental study and clinical observations of autologous hair follicle cell transplants to treat stable vitiligo[J]. Indian J Dermatol Venereol Leprol,2020, 86: 124-133.
[6] Thakur V, Kumar S, Kumaran MS, et al. Efficacy of transplantation of combination of noncultured dermal and epidermal cell suspension vs epidermal cell suspension alone in vitiligo: a randomized clinical trial[J]. JAMA Dermatol, 2019, 155: 204-210.
[7] Razmi M, Kumar R, Rani S, et al. Combination of follicular and epidermal cell suspension as a novel surgical approach in difficult-to-treat vitiligo: a randomized clinical trial[J]. JAMA Dermatol, 2018, 154: 301-308.
[8] Verma R, Grewal RS, Chatterjee M, et al. A comparative study of efficacy of cultured versus non cultured melanocyte transfer in the management of stable vitiligo[J]. Med J Armed Forces India, 2014, 70: 26-31.
[9] Shi HX, Zhang RZ, Xiao L, et al. Effects of keratinocyte-derived and fibroblast-derived exosomes on human epidermal melanocytes[J]. Indian J Dermatol Venereol Leprol, 2022, 88: 322-331.
[10] Takano K, Hachiya A, Murase D, et al. Quantitative changes in the secretion of exosomes from keratinocytes homeostatically regulate skin pigmentation in a paracrine manner[J]. J Dermatol, 2020, 47: 265-276.
[11] Zhang C, Zhou L, Huang J, et al. A preliminary study of growth characteristics of melanocytes co-cultured with keratinocytes in vitro[J]. J Cell Biochem, 2018, 119: 6173-6180.
[12] Zhu L, Lin X, Zhi L, et al. Mesenchymal stem cells promote human melanocytes proliferation and resistance to apoptosis through PTEN pathway in vitiligo[J].Stem Cell Res Ther, 2020, 11: 1-14.
[13] Kim H, Yi N, Do BR, et al. Adipose-derived stem cell coculturing stimulates integrin-mediated extracellular matrix adhesion of melanocytes by upregulating growth factors[J]. Biomol Ther (Seoul), 2019, 27: 185-192.
[14] Lommerts JE, Uitentuis SE, Bekkenk MW, et al. The role of phototherapy in the surgical treatment of vitiligo: a systematic review[J]. J Eur Acad Dermatol Venereol, 2018, 32: 1427-1435.
[15] Zhang D, Hong W, Fu L, et al. A randomized controlled study of the effects of different modalities of narrow-band ultraviolet B therapy on the outcome of cultured autologous melanocytes transplantation in treating vitiligo[J]. Dermatol Surg, 2014, 40: 420-426.
[16] Tawfik YM, Abd Elazim NE, Abdel-Motaleb AA, et al. The effect of NB-UVB on noncultured melanocyte and keratinocyte transplantation in treatment of generalized vitiligo using two different donor-to-recipient ratios[J]. J Cosmet Dermatol, 2019, 18: 638-646.
[17] Zhang B, Li T, Tang Y, et al. The effects of 308-nm excimer laser on the infiltration of CD4⁺, CD8⁺ T-cells, and regulatory T cells in the lesional skin of patients at active and stable stages of nonsegmental vitiligo[J].J Dermatolog Treat, 2021, 32: 580-584.
[18] Chang HC, Sung CW. Efficacy of combination therapy of narrowband-ultraviolet B phototherapy or excimer laser with topical tacrolimus for vitiligo: an updated systematic review and Meta-analysis[J]. Photodermatol Photoimmunol Photomed, 2021, 37: 74-77.
[19] Ebadi A, Rad MM, Nazari S, et al. The additive effect of excimer laser on non-cultured melanocyte-keratinocyte transplantation for the treatment of vitiligo: a clinical trial in an Iranian population[J]. J Eur Acad Dermatol Venereol, 2015, 29: 745-751.
[20] Zahra FT, Adil M, Amin SS, et al. Efficacy of topical 5% 5-fluorouracil with needling versus 5% 5-fluorouracil alone in stable vitiligo: a randomized controlled study[J].J Cutan Aesthet Surg, 2020, 13: 197.doi:10.4103/JCAS.JCAS-12_20.
[21] Attwa EM, Khashaba SA, Ezzat NA. Evaluation of the additional effect of topical 5-fluorouracil to needling in the treatment of localized vitiligo[J]. J Cosmet Dermatol, 2020, 19: 1473-1478.
[22] Albalat W, Elsayed M, Salem A, et al. Microneedling and 5-flurouracil can enhance the efficacy of non-cultured epidermal cell suspension transplantation for resistant acral vitiligo[J]. Dermatol Ther, 2022, 35: e15768.doi:10.1111/dth.15768.
[23] Mutalik S, Shah S, Sidwadkar V, et al. Efficacy of cyclosporine after autologous noncultured melanocyte transplantation in localized stable vitiligo-a pilot, open label, comparative study[J]. Dermatol Surg, 2017, 43: 1339-1347.
[24] Rekik M, Mseddi M, Kammoun N, et al. Efficacy of autologous platelet-rich plasma in the treatment of vitiligo: a 10-patient prospective study[J]. J Cosmet Dermatol, 2022, 21: 4225-4233.
[25] Albalat W, Elsayed M, Salem A, et al. Non-cultured epidermal cells suspended in either platelet-rich plasma or ringer lactate for stable vitiligo: a prospective comparative study[J]. J Cosmet Dermatol, 2022, 21: 3102-3109.

细胞移植联合其他治疗策略在治疗白癜风中的研究进展

Advances in cell transplantation combined with other therapeutic strategies in the treatment for vitiligo

PDF

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 14

编辑推荐

Metrics

本文评价

[1]	傅晨, 李平. 重型再生障碍性贫血治疗的研究进展[J]. 基础医学与临床, 2024, 44(5): 719-723.
[2]	陈小坤, 包新杰, 高俊, 李永宁. 神经干细胞移植治疗阿尔兹海默病的机制研究进展[J]. 基础医学与临床, 2023, 43(7): 1148-1151.
[3]	陆文琪, 万琳. 内皮损伤在移植物抗宿主病发生发展中作用的研究进展[J]. 基础医学与临床, 2023, 43(11): 1728-1732.
[4]	赵肖灵, 何润之, 孙玉姣, 张小冲, 杨林芳, 王瑞, 程芳. 活动期白癜风患者血清γ干扰素含量升高[J]. 基础医学与临床, 2022, 42(7): 1067-1070.
[5]	武坤, 聂波, 李云涛, 杨金荣, 程沈菊, 李艳红, 史明霞. 外周血miR-200c水平对移植异基因造血干细胞后急性移植物抗宿主病发生的预测作用[J]. 基础医学与临床, 2022, 42(6): 871-875.
[6]	房婷, 李响, 刘洁, 王皓. 鼠李糖乳杆菌通过调节肠道微生物群缓解造血干细胞移植后肝脏移植物抗宿主病[J]. 基础医学与临床, 2021, 41(9): 1303-1308.
[7]	邹雪莲, 胡雯, 雷子贤, 王红娟, 徐晨, 哈丽娜·海若拉, 康晓静. 山奈酚减轻人角质形成细胞氧化应激损伤[J]. 基础医学与临床, 2021, 41(8): 1103-1108.
[8]	傅明杰赵赫李志涛卢安卫蔡洪流董汉光. 不同方式移植骨髓间充质干细胞治疗急性重症胰腺炎大鼠的疗效对比[J]. 基础医学与临床, 2019, 39(10): 1474-1482.
[9]	康颖段明辉周道斌. 临床病例讨论（step by step）——自体干细胞移植后发热、呼吸困难[J]. 基础医学与临床, 2012, 32(10): 1216-1220.
[10]	苏津自林茂海林美萍. 移植转染ADM、HGF基因的骨髓间充质干细胞治疗大鼠心肌梗死[J]. 基础医学与临床, 2010, 30(2): 125-132.
[11]	王挹青李远鹏侯炳波郭晋村张鹏. 骨髓间充质干细胞移植对大鼠心梗后细胞因子VEGF、SDF-1、TGF-β1及心脏功能的影响[J]. 基础医学与临床, 2009, 29(10): 1050-1053.
[12]	何庚戌要彤张浩张晓玲胡盛寿. 骨髓间充质干细胞经大鼠冠状动脉内移植可行性研究[J]. 基础医学与临床, 2009, 29(1): 69-73.
[13]	王常珺卢姗冯铭韩钦魏俊吉王任直赵春华. 超顺磁性氧化铁标记人Flk-1+CD31-CD34-间充质干细胞对细胞增殖及向神经细胞分化的影响[J]. 基础医学与临床, 2008, 28(9): 930-935.
[14]	韩钦何东南刘艳宁李康华黎介寿赵春华. Flk-1+间充质干细胞和SP细胞参与肠道损伤修复的比较[J]. 基础医学与临床, 2008, 28(6): 563-569.