活动期白癜风患者血清γ干扰素含量升高

doi:10.16352/j.issn.1001-6325.2022.07.1067

基础医学与临床 ›› 2022, Vol. 42 ›› Issue (7): 1067-1070.doi: 10.16352/j.issn.1001-6325.2022.07.1067

活动期白癜风患者血清γ干扰素含量升高

赵肖灵¹, 何润之², 孙玉姣³, 张小冲⁴, 杨林芳³, 王瑞³, 程芳^3*

河北医科大学附属医院邢台市人民医院 1.肿瘤实验室; 2.神经外三科; 3.皮肤科; 4.科研与教学科, 河北邢台 054001

收稿日期:2021-01-04 修回日期:2021-10-15 出版日期:2022-07-05 发布日期:2022-06-29
通讯作者: * 1299233987@qq.com
基金资助:
河北省青年拔尖人才培养专项基金;2019年度河北省人才工程培养资助项目(A201902027);河北省“三三三人才”项目(A202002032)

Serum IFN-γ is increased in patients with active vitiligo

ZHAO Xiao-ling¹, HE Run-zhi², SUN Yu-jiao³, ZHANG Xiao-chong⁴, YANG Lin-fang³, WANG Rui³, CHENG Fang^3*

1. Cancer Laboratory; 2. Department 3 of Neurosurgery; 3. Department of Dermatology; 4. Department of Scientific Research and Teaching, Xingtai People's Hospital Affiliated to Hebei Medical University, Xingtai 054001, China

Received:2021-01-04 Revised:2021-10-15 Online:2022-07-05 Published:2022-06-29
Contact: * 1299233987@qq.com

摘要/Abstract

摘要： 目的探讨C-反应蛋白(CRP)、肿瘤坏死因子 α(TNF-α))、肿瘤坏死因子β(TNF-β)、E-钙黏附素(E-cad)、γ干扰素(IFN-γ)等细胞因子和CD8在白癜风患者血清中的含量变化。方法收集2017年5月至2018 年12月在邢台市人民医院皮肤科就诊的60例白癜风患者(活动期30例,稳定期30例)及体检中心健康人群对照组30例;采用ELISA检测血清中CRP、TNF-α、TNF-β、E-cad、IFN-γ和CD8因子含量。结果活动期组和稳定期组血清CRP、TNF-α、TNF-β、IFN-γ含量均显著升高(P＜0.05);活动期组血清IFN-γ含量显著高于稳定期组(P＜0.05);活动期组用药6个月后,血清IFN-γ含量较用药前显著降低(P＜0.05)。结论血清IFN-γ含量或可作为辅助评价白癜风活动性的实验室指标。

关键词: 白癜风, 细胞因子, 活动期, 发病机制

Abstract: Objective To examine serum C-reactive protein (CRP), tumor necrosis factor-α(TNF-α), tumor necrosis factor-β(TNF-β), E-cadherin (E-cad), human interferon-γ (IFN-γ) and cluster of differentiation 8 (CD8) in patients with vitiligo. Methods From May 2017 to December 2018, 60 patients with vitiligo (30 cases in active phase group and 30 cases in stable stage group) and 30 cases as control group collected from physical examination center joined the research program. The content of serum CRP, TNF-α, TNF-β, E-cad, IFN-γ and CD8 were compared among the three groups by enzyme-linked immunosorbent assay (ELISA). Results The content of serum CRP, TNF-α, TNF-β and IFN-γ in patients with active and stable vitiligo were significantly higher(P＜0.05). The content of serum IFN-γ in patients with active vitiligo was significantly higher than that in patients with stable vitiligo(P＜0.05)and significantly decreased after 6 months of treatment(P＜0.05). Conclusions The content of serum IFN-γ might be used as a biomarker in laboratory to evaluate the activity of vitiligo.

Key words: vitiligo, cytokines, active stage, pathogenesis

中图分类号:

R446.11

赵肖灵, 何润之, 孙玉姣, 张小冲, 杨林芳, 王瑞, 程芳. 活动期白癜风患者血清γ干扰素含量升高[J]. 基础医学与临床, 2022, 42(7): 1067-1070.

ZHAO Xiao-ling, HE Run-zhi, SUN Yu-jiao, ZHANG Xiao-chong, YANG Lin-fang, WANG Rui, CHENG Fang. Serum IFN-γ is increased in patients with active vitiligo[J]. Basic & Clinical Medicine, 2022, 42(7): 1067-1070.

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活动期白癜风患者血清γ干扰素含量升高

Serum IFN-γ is increased in patients with active vitiligo

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