薯蓣皂苷防治原发性骨质疏松的研究进展

doi:10.16352/j.issn.1001-6325.2022.06.021

基础医学与临床 ›› 2022, Vol. 42 ›› Issue (6): 960-963.doi: 10.16352/j.issn.1001-6325.2022.06.021

薯蓣皂苷防治原发性骨质疏松的研究进展

谢兴文^1,2, 钟建春^3*, 李鼎鹏^1,2, 黄睿³, 李宁³, 郭云龙³, 翟伯宇³

1.西北民族大学附属医院骨科,甘肃兰州 730030;
2.甘肃省第二人民医院骨科, 甘肃兰州 730046;
3.甘肃中医药大学中医临床学院, 甘肃兰州 730099

收稿日期:2021-03-04 修回日期:2021-07-09 出版日期:2022-06-05 发布日期:2022-06-02
通讯作者: * 1752709300@qq.com
基金资助:
国家自然科学基金(81860864);甘肃省科技计划(20JR5RA129);敦煌医学与转化教育部重点实验室开放课题(DHYX19-05);中央高校基本科研业务费项目(31920210041)

Research progress of dioscin in prevention and treatment of primary osteoporosis

XIE Xing-wen^1,2, ZHONG Jian-chun^3*, LI Ding-peng^1,2, HUANG Rui³, LI Ning³, GUO Yun-long³, ZHAI Bo-yu³

1. Department of Orthopaedics, the Affiliated Hospital of Northwest Minzu University, Lanzhou 730030;
2. Department of Orthopaedics, the Second People's Hospital of Gansu Province, Lanzhou 730046;
3. Clinical College of Chinese Medicine, Gansu University of Chinese Medicine,Lanzhou 730099,China

Received:2021-03-04 Revised:2021-07-09 Online:2022-06-05 Published:2022-06-02
Contact: * 1752709300@qq.com

摘要/Abstract

摘要： 薯蓣皂苷具有较强的抗感染、抗病毒、降脂、抗癌、降糖、抗血栓、抗衰老和保肝等活性,可通过延迟氧化应激保护心脏细胞免受缺血/再灌注损伤,成为治疗冠心病和心绞痛的补充及替代临床药物之一。近年来的研究表明,薯蓣皂苷通过抑制核因子-κB受体活化因子配体(RANKL)诱导的破骨细胞分化和促进成骨细胞分化来防治骨质疏松症(OP)。本文综述了薯蓣皂苷在抑制破骨细胞、促进成骨及相关信号通路方面防治骨质疏松的研究进展,以期为薯蓣皂苷与药食同源在OP防治中的临床应用提供思路。

关键词: 薯蓣皂苷, 山药, 骨质疏松, 药食同源, 信号通路

Abstract: Dioscin has strong anti infection, anti-virus, lipid-lowering, anti-cancer, hypoglycemic, antithrombotic, anti-aging and liver protective activities. It can protect cardiac cells from ischemia/reperfusion injury by delaying oxidative stress, and become one of the complementary and alternative clinical drugs for the treatment of coronary heart disease and angina pectoris. In recent years, studies have shown that dioscin can prevent osteoporosis(OP) by inhibiting RANKL induced osteoclast differentiation and promoting osteoblast differentiation. This paper reviews the research progress of dioscin in the prevention and treatment of osteoporosis in the aspects of inhibiting osteoclasts, promoting osteogenesis and related signaling pathways, in order to provide ideas for the development of a nutrition-medicine hybyrid strategy in the prevention and treatment of OP.

Key words: dioscin, dioscorea opposita, osteoporosis, nutrition-medicine hybrid strategy, signal pathway

中图分类号:

R274.9

谢兴文, 钟建春, 李鼎鹏, 黄睿, 李宁, 郭云龙, 翟伯宇. 薯蓣皂苷防治原发性骨质疏松的研究进展[J]. 基础医学与临床, 2022, 42(6): 960-963.

XIE Xing-wen, ZHONG Jian-chun, LI Ding-peng, HUANG Rui, LI Ning, GUO Yun-long, ZHAI Bo-yu. Research progress of dioscin in prevention and treatment of primary osteoporosis[J]. Basic & Clinical Medicine, 2022, 42(6): 960-963.

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薯蓣皂苷防治原发性骨质疏松的研究进展

Research progress of dioscin in prevention and treatment of primary osteoporosis

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