生物钟紊乱致心脏功能障碍的研究进展

doi:10.16352/j.issn.1001-6325.2022.05.005

基础医学与临床 ›› 2022, Vol. 42 ›› Issue (5): 799-803.doi: 10.16352/j.issn.1001-6325.2022.05.005

生物钟紊乱致心脏功能障碍的研究进展

梁清, 陈丽红^*

大连医科大学医学科学研究院, 辽宁大连 116044

收稿日期:2020-10-28 修回日期:2021-04-09 出版日期:2022-05-05 发布日期:2022-04-28
通讯作者: * lihong@dmu.edu.cn
基金资助:
国家重点研发计划(2019YFA0802400)

Advances in research on relationship of circadian disruption with cardiac dysfunction

LIANG Qing, CHEN Li-hong^*

Advanced Institute for Medical Sciences, Dalian Medical University, Dalian 116044, China

Received:2020-10-28 Revised:2021-04-09 Online:2022-05-05 Published:2022-04-28
Contact: * lihong@dmu.edu.cn

摘要/Abstract

摘要： 生物钟紊乱与心血管疾病密切相关,无论是内源性生物钟基因改变还是外源性环境因素引起的生物钟异常均可增加心脏不良事件的发生风险,如心肌梗死、心率失常、心源性猝死等,其发生机制主要与直接影响心脏本身功能或间接影响机体整体代谢状态有关。

关键词: 生物钟紊乱, 心脏功能, 心血管疾病

Abstract: Accumulating evidence has shown that disruption of the circadian timing system by either endogenous genetic variants or exogenous environmental factors is significantly associated with increased risk of cardiovascular diseases, such as myocardial infarction, arrhythmia, sudden cardiac death and so on. It is of great significance to understanding the relationship between circadian disruption and cardiovascular function and disease.

Key words: circadian disruption, cardiac function, cardiovascular disease

中图分类号:

R363.2

梁清, 陈丽红. 生物钟紊乱致心脏功能障碍的研究进展[J]. 基础医学与临床, 2022, 42(5): 799-803.

LIANG Qing, CHEN Li-hong. Advances in research on relationship of circadian disruption with cardiac dysfunction[J]. Basic & Clinical Medicine, 2022, 42(5): 799-803.

参考文献

[1] 丁健明.光照对哺乳类动物生物钟的调节机制[J].基础医学与临床,2005,25:577-586.
[2] West AC, Smith L, Ray DW, et al. Misalignment with the external light environment drives metabolic and cardiac dysfunction[J]. Nat Commun, 2017, 8:417.doi:10.1038/s41467-017-00462-2.
[3] Penev PD, Kolker DE, Zee PC, et al. Chronic circadian desynchronization decreases the survival of animals with cardiomyopathic heart disease[J]. Am J Physiol, 1998, 275:H2334-H2337.
[4] Alibhai FJ, Tsimakouridze EV, Chinnappareddy N, et al. Short-term disruption of diurnal rhythms after murine myocardial infarction adversely affects long-term myocardial structure and function[J]. Circ Res, 2014, 114:1713-1722.
[5] Martino TA, Oudit GY, Herzenberg AM, et al. Circadian rhythm disorganization produces profound cardiovascular and renal disease in hamsters[J]. Am J Physiol Regul Integr Comp Physiol, 2008, 294:R1675-R1683.
[6] Viola AU, James LM, Archer SN, et al. PER3 polymorphism and cardiac autonomic control: effects of sleep debt and circadian phase[J]. Am J Physiol Heart Circ Physiol, 2008, 295:H2156-H2163.
[7] Yang G, Chen L, Grant GR, et al. Timing of expression of the core clock gene Bmal1 influences its effects on aging and survival[J]. Sci Transl Med, 2016, 8:324ra16.doi:10.1126/scitranslmed.add3305.
[8] Curtis AM, Cheng Y, Kapoor S, et al. Circadian variation of blood pressure and the vascular response to asynchro-nous stress[J]. Proc Natl Acad Sci U S A, 2007, 104:3450-3455.
[9] Schroder EA, Burgess DE, Zhang X, et al. The cardiomyocyte molecular clock regulates the circadian expression of Kcnh2 and contributes to ventricular repolarization[J]. Heart Rhythm, 2015, 12:1306-1314.
[10] Bray MS, Shaw CA, Moore MWS, et al. Disruption of the circadian clock within the cardiomyocyte influences myocardial contractile function, metabolism, and gene expression[J]. Am J Physiol Heart Circ Physiol, 2008, 294:H1036-H1047.
[11] Durgan DJ, Pulinilkunnil T, Villegas-Montoya C, et al. Short communication: ischemia/reperfusion tolerance is time-of-day-dependent: mediation by the cardiomyocyte circadian clock[J]. Circ Res, 2010, 106:546-550.
[12] Eckle T, Hartmann K, Bonney S, et al. Adora2b-elicited Per2 stabilization promotes a HIF-dependent metabolic switch crucial for myocardial adaptation to ischemia[J]. Nat Med, 2012, 18:774-782.
[13] Reitz CJ, Alibhai FJ, Khatua TN, et al. SR9009 administered for one day after myocardial ischemia-reperfusion prevents heart failure in mice by targeting the cardiac inflammasome[J]. Commun Biol, 2019, 2:353.doi:10.1068/s42003-019-0595-z.
[14] Stujanna EN, Murakoshi N, Tajiri K, et al. Rev-erb agonist improves adverse cardiac remodeling and survival in myocardial infarction through an anti-inflammatory mechanism[J]. PLoS One, 2017, 12:e0189330. doi: 10.1371/journal.pone.0189330.
[15] Alibhai FJ, LaMarre J, Reitz CJ, et al. Disrupting the key circadian regulator CLOCK leads to age-dependent cardiovascular disease[J]. J Mol Cell Cardiol, 2017, 105:24-37.
[16] Ingle KA, Kain V, Goel M, et al. Cardiomyocyte-specific Bmal1 deletion in mice triggers diastolic dysfunction, extracellular matrix response, and impaired resolution of inflammation[J]. Am J Physiol Heart Circ Physiol, 2015, 309:H1827-H1836.
[17] Alibhai FJ, Reitz CJ, Peppler WT, et al. Female ClockDelta19/Delta19 mice are protected from the development of age-dependent cardiomyopathy[J]. Cardiovasc Res, 2018, 114:259-271.
[18] Li E, Li X, Huang J, et al. BMAL1 regulates mitochondrial fission and mitophagy through mitochondrial protein BNIP3 and is critical in the development of dilated cardiomyopathy[J]. Protein Cell, 2020, 11:661-679.
[19] Lefta M, Campbell KS, Feng HZ, et al. Development of dilated cardiomyopathy in Bmal1-deficient mice[J]. Am J Physiol Heart Circ Physiol, 2012, 303:H475-H485.
[20] Sato F, Kohsaka A, Bhawal UK, et al. Potential roles of Dec and Bmal1 genes in interconnecting circadian clock and energy metabolism[J]. Int J Mol Sci, 2018, 19:781. doi: 10.3390/ijms19030781.
[21] Qiao L, Guo B, Zhang H, et al. The clock gene, brain and muscle Arnt-like 1, regulates autophagy in high glucose-induced cardiomyocyte injury[J]. Oncotarget, 2017, 8:80612-80624.
[22] Young ME, Wilson CR, Razeghi P, et al. Alterations of the circadian clock in the heart by streptozotocin-induced diabetes[J]. J Mol Cell Cardiol, 2002, 34:223-231.
[23] Hermida RC, Crespo JJ, and Dominguez-Sardina M. Improved reduction of cardiovascular risk by bedtime ingestion of ARB and ACEI medication class therapies[J]. Eur Heart J, 2020, 41:1602-1603.
[24] Montaigne D, Marechal X, Modine T, et al. Daytime variation of perioperative myocardial injury in cardiac surgery and its prevention by Rev-Erbalpha antagonism: a single-centre propensity-matched cohort study and a randomised study[J]. Lancet, 2018, 391:59-69.

生物钟紊乱致心脏功能障碍的研究进展

Advances in research on relationship of circadian disruption with cardiac dysfunction

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