基础医学与临床 ›› 2022, Vol. 42 ›› Issue (11): 1751-1754.doi: 10.16352/j.issn.1001-6325.2022.11.1751

• 研究论文 • 上一篇    下一篇

张家界市普通型/重型德尔塔新型冠状病毒肺炎与血清白蛋白相关性分析

陈宇舟1,3, 戴靖榕2, 李茜3, 梁雅婷1,3, 吴松林1,3*   

  1. 1.湖南师范大学 医学院,湖南 长沙 410081;
    2.昆明理工大学 医学院, 云南 昆明 650500;
    3.张家界市人民医院 耳鼻喉科, 湖南 张家界 427000
  • 收稿日期:2021-11-26 修回日期:2022-04-07 出版日期:2022-11-05 发布日期:2022-11-01
  • 通讯作者: * 372959352@qq.com

Correlation analysis of common/severe COVID-19 delta with serum albumin in Zhangjiajie

CHEN Yu-zhou1,3, DAI Jing-rong2, LI Qian3, LIANG Ya-ting1,3, WU Song-lin1,3*   

  1. 1. School of Medicine, Hunan Normal University,Changsha 410081;
    2. Medical School, Kunming University of Science and Technology, Kunming 650500;
    3. Departmengt of Otolaryngology, Zhangjiajie People's Hospital, Zhangjiajie 427000,China
  • Received:2021-11-26 Revised:2022-04-07 Online:2022-11-05 Published:2022-11-01
  • Contact: * 372959352@qq.com

摘要: 目的 分析张家界市德尔塔(delta)新型冠状病毒肺炎(COVID-19)(简称德尔塔新冠肺炎)分型与确诊病例一般情况、临床特征差异的相关性。方法 纳入2021年7月20日至2021年9月30日73例张家界市人民医院确诊的德尔塔COVID-19患者,根据《新型冠状病毒感染的肺炎诊疗方案(试行第八版)》诊断及分型标准,分为轻型组和普通型/重型组,比较两组患者的一般情况、临床表现、化验指标差异的相关性。结果 在73例病例中,轻型组22例(30.1%),普通型/重型组51例(69.9%),两组间的年龄、性别、球蛋白、白蛋白、纤维蛋白原、淀粉样蛋白A、C反应蛋白、血沉、D-二聚体的比较均有差异(P<0.05)。二元Logistic回归分析结果显示血清白蛋白是普通型/重型德尔塔新冠肺炎患者的独立影响因素(OR=0.762,95% CI:0.585~0.993,P<0.05)。结论 血清白蛋白是普通型/重型德尔塔新冠肺炎的保护性因素;补充白蛋白可能对预防普通型/重型德尔塔新冠肺炎具有重要作用。

关键词: 新型冠状病毒肺炎, 新冠病毒delta变异株, 血清白蛋白

Abstract: Objective To analyze the correlation between the classification of infection by delta variant of coronavirus disease 2019(COVID-19 delta) in Zhangjiajie City and the differences in general health conditions and clinical characteristics of confirmed cases. Methods Seventy-three confirmed patients admitted to Zhangjiajie People's Hospital from July 20, 2021 to September 30, 2021 were enrolled into this research project. According to the diagnostic and typing criteria of Novel Coronavirus Protocol for the Diagnosis and Treatment of Pneumonia (Trial Edition 8), the patients were classified as mild, ordinary and severe groups and compared for general condition, clinical manifestations and laboratory data. Results Of the 73 patients, 22 (30.1%) were in the mild group and 51 (69.9%) were in the normal and severe groups. There were statistically significant differences in age, gender, globulin, albumin, fibrinogen, amyloid A, C-reactive protein, ESR and D-dimer between the two groups (P<0.05).Binary Logistic regression analysis showed that serum albumin was an independent influencing factor for common/severe group (OR=0.762,95% CI:0.585~0.993, P<0.05). Conclusions Serum albumin is a protective factor for infection by common/severe COVID-19 delta variant. Albumin supplementation may play an important role in the prevention of ordinary/severe of COVID-19 delta.

Key words: coronavirus disease 2019, delta variant of novel-coronavirus, serum albumin

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