基础医学与临床 ›› 2019, Vol. 39 ›› Issue (1): 7-10.

• 研究论文 • 上一篇    下一篇

LSD1在人直肠腺癌组织中高表达

顾晨文,刘现立   

  1. 河南科技大学第一附属医院新区医院
  • 收稿日期:2017-12-07 修回日期:2018-05-07 出版日期:2019-01-05 发布日期:2018-12-28
  • 通讯作者: 刘现立 E-mail:doctliu@163.com

High expression of LSD1 in human rectal adenocarcinoma

  • Received:2017-12-07 Revised:2018-05-07 Online:2019-01-05 Published:2018-12-28

摘要: 目的 分析赖氨酸特异性组蛋白去甲基化酶1(LSD1)在直肠腺癌中的高表达及其临床意义。方法 在直肠腺癌及其癌旁组织中用q-PCR检测LSD1 mRNA的表达,用western blot和免疫组化检测LSD1蛋白的表达及其与直肠腺癌临床病理特征和预后的相关性。结果 直肠腺癌组织中LSD1 mRNA及蛋白表达水平显著高于癌旁组织(P < 0.05),其高表达与肿瘤分化程度、淋巴结转移、浸润深度及TNM分期显著相关(P < 0.05)。LSD1高表达患者预后较差(P < 0.05)。结论 LSD1的高表达可能促进了直肠腺癌的发生发展,抑制LSD1可能是直肠腺癌靶向治疗的潜在分子靶点之一。

关键词: 直肠腺癌, LSD1, 预后

Abstract: Objective To analyze the high expression of lysine - specific histone demethanase 1(LSD1) in rectal adenocarcinoma and its clinical significance. Method The mRNA expression of LSD1 was detected by q-PCR in rectal adenocarcinoma and its adjacent tissues. The expression of LSD1 protein was detected by western blot and immunohistochemistry, and the correlation between the expression of LSD1 protein and clinicopathological features and prognosis of rectal adenocarcinoma was analyzed. Result The mRNA and protein expression of LSD1 in rectal adenocarcinoma was significantly higher than that in (P < 0.05). High expression of LSD1 was significantly correlated with the degree of tumor differentiation, lymph node metastasis, depth of invasion and TNM staging (P < 0.05). The prognosis of patients with high expression of LSD1 was poor (P < 0.05). Conclusions High expression of LSD1 may promote the occurrence and development of rectal adenocarcinoma, and inhibition of LSD1 may be one of the potential molecular targets for targeted therapy of rectal adenocarcinoma.

Key words: rectal adenocarcinoma, LSD1, prognosis

中图分类号: